巨噬细胞代谢重编程在心肌梗死中的作用  

The role of macrophage metabolic reprogramming in myocardial infarction

作　　者：邹子聪 辜慕阳 程翔[1,2,3] ZOU Zicong;GU Muyang;CHENG Xiang(Department of Cardiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Hubei Key Laboratory of Biological Targeted Therapy,Wuhan 430022,China;Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院心内科,武汉430022 [2]生物靶向治疗研究湖北省重点实验室,武汉430022 [3]心血管疾病免疫诊疗湖北省工程研究中心,武汉430022

出　　处：《广西医科大学学报》2024年第11期1470-1476,共7页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.82200320)。

摘　　要：心肌梗死(MI)作为威胁人类生命健康的主要心血管疾病之一,MI后的免疫炎症反应影响着其发展和预后。尽管炎症反应为组织修复所必需,但持续的炎症激活将加剧心脏负性重构的进程,成为MI后心力衰竭发生的重要因素。巨噬细胞作为重要的固有免疫细胞之一,其在MI后的免疫应答、坏死组织清除和组织修复等过程中发挥着至关重要的作用。在适应MI后组织微环境、响应活化信号和发挥功能的过程中,巨噬细胞的代谢特征发生重大改变。巨噬细胞在MI后应对微环境变化的代谢适应机制,也是其表型和功能可塑性的基础,使其能在MI后各阶段发挥不同作用。本文综述了巨噬细胞在MI中的代谢重编程现象,及其对MI后的免疫炎症调节和组织修复的影响,为开发靶向巨噬细胞的治疗策略提供更多的视角和科学依据。Myocardial infarction(MI)is one of the major cardiovascular diseases that threaten human health and the post-MI inflammation affects its progression and prognosis.Although the inflammatory response is necessary for tissue repair,persistent inflammatory activation exacerbates the process of cardiac remodeling and serves as an important factor of heart failure after MI.Macrophages,as one of the important innate immune cells,play a crucial role in the immune response,necrotic tissue clearance,and tissue repair after MI.While adapting to the post-MI microenvironment,responding to activation signals,and exerting functions,the metabolic phenotype of macrophages undergo significant changes.The metabolic reprogramming mechanism of macrophages in response to microenvironmental changes after MI is also the basis for their phenotypic and functional plasticity,allowing them to play different roles at various stages after MI.This review summarizes the phenomenon of metabolic reprogramming in macrophages after MI and its impact on the regulation of inflammation and tissue repair after MI,providing more perspectives and scientific evidence for the development of macrophage-targeted therapeutic strategies.

关 键 词：心肌梗死 巨噬细胞 代谢重编程 炎症 

分 类 号：R542.22[医药卫生—心血管疾病]