间充质干细胞外泌体在心脏移植排斥反应中的作用研究进展  

Progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejection

作　　者：刘德昭 曾志羽[1] LIU Dezhao;ZENG Zhiyu(Department of Cardiovascular Medicine,the First Affiliated Hospital of Guangxi Medical University,Guangxi Key Laboratory of Precision Medicine for Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院心血管内科,广西心脑血管疾病防治精准医学重点实验室,南宁530021

出　　处：《广西医科大学学报》2024年第11期1477-1482,共6页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.81960082);广西心脑血管疾病防治精准医学重点实验室资助项目(No.22-035-18);广西心脑血管疾病临床医学研究中心资助项目(No.AD17129014);广西医学高层次骨干人才“139”计划资助项目(No.G201901006)。

摘　　要：心脏移植是治疗终末期心力衰竭患者的有效治疗手段,但面临器官短缺和排斥反应等挑战。间充质干细胞(MSCs)因其免疫调节活性,有望成为一种减轻心脏移植排斥反应的治疗方法,但其临床应用也受限于过继后MSCs存活率低和归巢效率不足等问题。外泌体(Exos)是细胞间信息递送的重要载体,具有低免疫原性和高稳定性等优点。MSCs分泌的Exos(MSCexos)能有效传递免疫调节分子,促进组织修复和免疫耐受,从而减轻心脏移植排斥反应。研究表明,MSC-exos可有效克服MSCs细胞疗法的不足,有望成为更好减轻心脏移植排斥反应的新方式。因此,本文对心脏移植的研究现状和近年来MSCexos在心脏移植领域的研究进展进行综述,以期为更好的提高心脏移植患者存活率提供新的思路。Heart transplantation is an effective treatment for patients with end-stage heart failure,but faces challenges such as organ shortage and rejection.Mesenchymal stem cells(MSCs)hold promise as a potential therapy for attenuating heart transplant rejection due to their immunomodulatory activity.However,their clinical application is limited by issues such as the low MSC survival rate and insufficient homing efficiency after the transplantation.Exosomes(Exos)are important carriers for intercellular information delivery,with the advantages of low immunogenicity and high stability.MSC-exos can effectively deliver immunomodulatory molecules,promote tissue repair and immune tolerance,and thus attenuate heart transplant rejection.Studies have shown that MSC-exos can effectively overcome the deficiencies of MSCs cell therapy and are expected to be a new way to better attenuate heart transplant rejection.Therefore,this article reviews the current research status of heart transplantation and the research progress of MSC-exos in the field of heart transplantation in recent years,with the aim of providing new ideas to better improve the survival rate of heart transplant patients.

关 键 词：心脏移植 排斥反应 间充质干细胞 外泌体 

分 类 号：R541.6[医药卫生—心血管疾病]