靶向肿瘤相关巨噬细胞在癌症免疫治疗中的研究进展  

Progress in targeting tumor-associated macrophages in cancer immunotherapy

作　　者：张丝雨 周琼[1] ZHANG Siyu;ZHOU Qiong(Department of Respiratory and Critical Care Medicine,Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院呼吸与危重症医学科,武汉430022

出　　处：《广西医科大学学报》2024年第11期1549-1557,共9页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.82370095)。

摘　　要：巨噬细胞作为免疫细胞的一员,在抵抗病原入侵和激活T细胞介导的适应性免疫反应中发挥重要作用。在肿瘤微环境中,巨噬细胞在肿瘤发生和肿瘤进展中发挥复杂的作用。肿瘤相关巨噬细胞主要通过促进肿瘤细胞生长和抑制淋巴细胞的肿瘤杀伤效应来促进肿瘤进展。因此,肿瘤相关巨噬细胞成为癌症免疫治疗的重要靶点。目前,针对肿瘤相关巨噬细胞的治疗策略主要分为抑制促肿瘤型巨噬细胞和激活抗肿瘤型巨噬细胞。本文总结了靶向肿瘤相关巨噬细胞在肿瘤免疫治疗中的可行策略,并强调了靶向肿瘤相关巨噬细胞治疗与其他治疗的协同作用。As the member of immune cells,macrophages are necessary to fight against pathogenic invasion and activate T cell-mediated adaptive immune responses.In the tumor microenvironment(TME),macrophages play a complex role in tumorigenesis and tumor progression.Tumor-associated macrophages(TAMs)can promote tumor progression through supporting the growth of tumor cells and inhibiting the tumoricidal activity of lymphocytes.Therefore,TAMs become an important target for cancer immunotherapy.TAMs-targeted therapeutic strategies comprise pro-tumor TAMs inhibition and anti-tumor TAMs activation.This article summarizes the feasible strategies of targeting TAMs in cancer immunotherapy and highlights the synergistic effect of TAMs-targeted therapy with other immunotherapies.

关 键 词：癌症 肿瘤相关巨噬细胞 免疫治疗 

分 类 号：R979.1[医药卫生—药品]