滋肾育胎丸对PCOS不孕患者血清性激素结合球蛋白、血清淀粉样蛋白P水平及内膜容受性的影响  

The effects of Zishen Yutai Pill on SHBG and SAP levels and endometrial receptivity in infertile patients with PCOS

作　　者：王婉娟 张欣悦 李鑫 刘金 刘幸 陈梦捷 WANG Wan-juan;ZHANG Xin-yue;LI Xin;LIU Jin;LIU Xing;CHEN Meng-jie(Department of Pharmacy,Northwest Women&Children’s Hospital,Xi’an 710061;Department of Pharmacy,Xi’an Hospital of Traditional Chinese Medicine,Xi’an 710021;Department of Pharmacy,Xi’an Children’s Hospital,Xi’an 710002;Department of Gynaecology,Xi’an Hospital of Traditional Chinese Medicine,Xi’an 710021)

机构地区：[1]西北妇女儿童医院药剂科,西安710061 [2]西安市中医医院药剂科,西安710021 [3]西安市儿童医院药剂科,西安710002 [4]西安市中医医院妇科,西安710021

出　　处：《生殖医学杂志》2024年第11期1484-1489,共6页Journal of Reproductive Medicine

基　　金：陕西省重点研发计划项目(2022SF-163)。

摘　　要：目的 探讨滋肾育胎丸对多囊卵巢综合征(PCOS)合并不孕患者血清性激素结合球蛋白(SHBG)、血清淀粉样蛋白P(SAP)水平及子宫内膜容受性的影响,以期为PCOS合并不孕患者的治疗提供新的思路。方法 选择2021年1月至2023年12月期间西北妇女儿童医院收治的102例PCOS合并不孕患者为研究对象。采用随机数字表法,将患者分为研究组(采用来曲唑+滋肾育胎丸干预,51例)和对照组(仅采用来曲唑干预,51例)。检测两组患者治疗前后的SAP、SHBG水平、性激素(FSH、LH、雌二醇)水平、子宫内膜厚度、切面卵泡数目及卵巢间质面积/卵巢总面积(SA/TA),记录两组患者治疗后的排卵率、临床妊娠率、早孕流产率。结果 两组患者的年龄、体质量指数(BMI)、不孕类型、不孕年限比较均无显著性差异(P>0.05)。治疗前,两组患者间血清SHBG、SAP及性激素水平、子宫内膜厚度/类型、卵巢超声表现等指标比较均无显著性差异(P>0.05)。治疗后,研究组患者血清SHBG、LH水平显著高于对照组(P<0.05),SAP水平显著低于对照组(P<0.05),而两组患者间血清FSH、雌二醇水平比较无显著性差异(P>0.05)。治疗后,研究组患者子宫内膜厚度显著高于对照组患者(P<0.05),子宫内膜A型占比显著大于对照组(P<0.05),双侧卵巢的平均体积、SA/TA和卵泡数目均显著低于对照组(P<0.05)。治疗后,研究组的临床妊娠率(28.33%vs.12.70%)、排卵率(86.67%vs.69.84%)显著高于对照组(P<0.05),流产率(10.00%vs.25.40%)则显著低于对照组(P<0.05)。结论 滋肾育胎丸能有效调整PCOS合并不孕患者的SAP、SHBG水平,改善子宫内膜容受性。Objective:To investigate the effects of Zishen Yutai Pill on the levels of serum amyloid P(SAP)and sex hormone binding globulin(SHBG),as well as endometrial receptivity in patients with PCOS complicated with infertility,in order to provide a new approach to the treatment of PCOS infertility patients.Methods:From January 2021 to December 2023,102 infertile patients with PCOS treated at the Northwest Women’s and Children’s Hospital were selected as subjects.They were randomly divided into the study group(51 patients treated with letrozole and Zishen Yutai Pills)and the control group(51 patients treated with letrozole alone).Levels of SAP,SHBG,sex hormones(FSH,LH,estradiol),endometrial thickness,follicle count on cross-section,and the ratio of ovarian stroma area to total ovarian area(SA/TA)were measured before and after treatment.The ovulation rate,clinical pregnancy rate,and early miscarriage rate were also recorded for both groups.Results:There were no significant differences between the two groups in terms of age,body mass index(BMI),type of infertility,duration of infertility(P>0.05).Before treatment,there were no significant differences between the two groups in serum levels of SHBG,SAP,sex hormones,endometrial thickness/type,and ovarian ultrasound findings(P>0.05).After treatment,the serum SHBG and LH levels in the study group were significantly higher than those in the control group(P<0.05),and SAP level was significantly lower(P<0.05).There were no significant differences in serum FSH or estradiol levels between the two groups(P>0.05).The endometrial thickness and the proportion of type A endometrium in the study group were significantly greater than those in the control group(P<0.05).The average volume of both ovaries,SA/TA ratio,and the number of follicles in the study group were significantly lower than those in the control group(P<0.05).The clinical pregnancy rate(28.33%vs.12.70%)and the ovulation rate(86.67%vs.69.84%)were significantly higher in the study group than those in the control group(P<0.0

关 键 词：滋肾育胎丸 多囊卵巢综合征 不孕 血清淀粉样蛋白P 血清性激素结合球蛋白 

分 类 号：R711.75[医药卫生—妇产科学]