"Cap and glycosylate"strategy for direct radical functionalization of native sugars  

“封端-糖基化”策略实现天然糖类的自由基官能团化

作　　者：Hiroaki Matoba Go Hirai 

机构地区：[1]Graduate School of Pharmaceutical Sciences,Kyushu University,Fukuoka 812-8582,Japan

出　　处：《Science Bulletin》2024年第20期3163-3165,共3页科学通报（英文版）

摘　　要：Glycoconjugates are biologically significant molecules,but their precise role in many biological phenomena remains unclear,largely due to their heterogeneity and complexity,as well as the dynamic enzymatic remodeling/hydrolysis of glycan structures.Thus,for mechanistic studies,it is desirable to use metabolically stable mimics of glycoconjugates.In this context,S-,Se-,and notably C-linked glycoconjugates have emerged as attractive targets,leading to the development of numerous synthetic methods[1–3].

关 键 词：SUGAR HYDROLYSIS ATTRACTIVE 

分 类 号：O629.1[理学—有机化学]