Nanowire-mediated miRNA delivery  

作　　者：Yuan Wang Bing Chen 

机构地区：[1]Laboratory for Biomaterials and Drug Delivery,Department of Anesthesiology,Division of Critical Care Medicine,Boston Children’s Hospital,Harvard Medical School,Boston 02115,USA [2]College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology),Nanjing University of Posts and Telecommunications,Nanjing 210023,China

出　　处：《Science China(Life Sciences)》2024年第11期2532-2534,共3页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(62205155);the Natural Science Research Start-up Foundation of Recruiting Talents of Nanjing University of Posts and Telecommunications(NY222104).

摘　　要：In the ever-evolving nanomedicine and biotechnology,the pursuit of advanced drug delivery systems that induce precise positioning and targeting in the complex biological landscape for personalized and efficient therapies has become a paramount endeavor(Vargason et al.,2021).Central to this trend is the delivery of functional microRNAs(miRNAs),which play crucial roles in regulating gene expression(Li et al.,2021).Specifically,by binding to target messenger RNAs(mRNAs),miRNAs can control protein synthesis or lead to mRNA degradation through various cellular processes such as differentiation,proliferation,apoptosis,and immune responses.These processes are essential for regenerative medicine,immune modulation,and disease treatment(e.g.,cancers,chronic infections and autoimmune disorders)where gene expression is dysregulated(Kara et al.,2022).

关 键 词：PRECISE LANDSCAPE 

分 类 号：R318[医药卫生—生物医学工程]