Nontoxic chemical crosslinked bacterial cellulose-heparin-gelatin composite hydrogel as antibacterial dressing  

作　　者：Ruixuan Liu Jingting Cai Nana Qin Kexin Zhang Tongyang Li Hao Luo Dadang Guo 

机构地区：[1]State Key Laboratory for Mechanical Behavior of Materials,School of Materials Science and Engineering,Xi'an Jiaotong University,Xi'an 710049,China [2]Northwest Institute for Non-ferrous Metal Research,Xi'an 710016,China [3]College of fashion and art design,Xi'an Polytechnic University,Xi'an 710048,China [4]Frontier Institute of Science and Technology,Xi'an Jiaotong University,Xi'an 710049,China.

出　　处：《Journal of Materials Science & Technology》2024年第11期29-38,共10页材料科学技术（英文版）

基　　金：Science and Technology Program of Shaanxi Province(No.2019GY-200).

摘　　要：A hydrogel dressing based on bacterial cellulose(BC),which is grafted with quaternary ammonium func-tional and crosslinked with the gelatin-heparin system,is prepared to provide the features mainly con-cerning softness,high swelling ratio,antibacterial property,and biocompatibility.An innovation of prepa-ration is that the BC is beaten into short-chain scaffolds to improve the efficiency of grafting,which not only simplifies the preparation process but also avoids the biotoxicity caused by the introduction of toxic catalyst such as dimethyl sulfoxide(DMSO)or uncertain toxic side products in long-chain graft-ing.Scanning electron microscopy(SEM)shows that the QBC/Hep/Gel composite hydrogel possesses a three-dimensional mesh structure with high porosity.The hydrogel shows outstanding water manage-ment performance indicated by the swelling ratio of 1476%,water retention ratio of more than 90%at 120 h,and moisture permeability of 3296 g m^(-2) 24 h^(-1).The antibacterial experiment is implemented with staphylococcus aureus,and the antibacterial effect is represented by an inhibition zone of 3 cm in diameter.In vivo animal experiments suggested that QBC/Hep/Gel could effectively promote epithelial reconstruction,collagen deposition,and angiogenesis in normal wounds,reduce inflammation,and ac-celerate wound healing.All these results indicate that the proposed QBC/Hep/Gel hydrogel is a potential composite for antibacterial dressing.

关 键 词：Antibacterial dressings Hydrogel dressings Wound healing Cross-linking 

分 类 号：TQ340.64[化学工程—化纤工业] TB332[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]