In situ growth of nano-hydroxyapatite on multilayered Ti_(3)C_(2)T_(x) MXene as a drug carrier with superior-performance  

作　　者：Xiaowei Liu Ruixue Sun Zeao Zhou Yuanzheng Tang 

机构地区：[1]College of Materials Science and Engineering,Qingdao University of Science and Technology,Qingdao 266042,China [2]College of Electromechanical Engineering,Qingdao University of Science and Technology,Qingdao 266061,China

出　　处：《Journal of Materials Science & Technology》2024年第13期91-101,共11页材料科学技术（英文版）

基　　金：Shandong Provincial Natural Science Foundation,China(No.ZR2021ME053).

摘　　要：Bone defects caused by tumor resection typically require bone repair materials to fill the defect sites.The development of multifunctional bone filling materials with integrated chemotherapy,photohermal therapy,and guided bone regeneration is very necessary and urgently needed.Herein,for the first time,the construction of novel multilayered Ti_(3)C_(2)T_(x) MXene(m-MXene)/nano-hydroxyaptite(nHAp)composites(m-MXene/nHAp)for bone repair is reported.The in situ growth of nHAp on multilayered Ti_(3)C_(2)T_(x) MXene is achieved through a facile hydrothermal method without using any organic additives.Due to the syner-gistic effects of nHAp and m-MXene,the m-MXene/nHAp composites show superior drug carrier perfor-mance with ultra-high drug loading capacity and ultra-long drug sustained release time.The molecular dynamics simulation results indicate that both Ti_(3)C_(2)T_(x) MXene and HAp show many adsorption sites and high binding energy with DOX.Moreover,the m-MXene/nHAp composites possess high photothermal conversion efficiency and excellent photothermal stability.The in situ growth of nano-HAp can signifi-cantly improve the biocompatibility of the m-MXene.The as-prepared multifunctional m-MXene/nHAp composites in this work can be used as bone filling powder and have great potential in bone defect reconstruction caused by bone tumor.

关 键 词：Multilayered Ti_(3)C_(2)T_(x)MXene NANO-HYDROXYAPATITE In situ growth Drug carrier Photothermal property 

分 类 号：O643.36[理学—物理化学]