基于数据挖掘探讨2型糖尿病合并非酒精性脂肪性肝病的中医用药规律  

Exploration of TCM Prescription Patterns for Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease Based on Data Mining

作　　者：谢菊 彭思涵 刘桠[1] 谢春光[1] XIE Ju;PENG Si-han;LIU Ya;XIE Chun-guang(Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China)

机构地区：[1]成都中医药大学,四川成都610072

出　　处：《云南中医中药杂志》2024年第10期22-28,共7页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：中国博士后科学基金(2023MD734104);四川省博士后创新人才支持项目(BX202205);成都中医药大学附属医院院基金(23YY38)。

摘　　要：目的利用“中医传承辅助平台(V2.5)”挖掘中医药治疗2型糖尿病合并非酒精性脂肪性肝病的用药规律,探索新组方为临床治疗提供思路。方法检索建库至2023年10月31日期间中国知网(CNKI)、维普(VIP)、万方数据知识服务平台(WanFang Data)中与中医药治疗2型糖尿病合并非酒精性脂肪性肝病相关的文献,将数据整理后录入“中医传承辅助平台(V2.5)”,通过建立独立的数据库对录入数据进行归纳与分析,挖掘用药规律。结果筛选出处方81首,涉及药物137味;使用频次排在前10位的是丹参、柴胡、黄芪、山楂、黄连、白术、茯苓、泽泻、白芍、郁金;药性多以寒、温、平为主,药味多苦甘辛,使用药物主要归脾、肝、胃经;并通过层次聚类分析挖掘出6个核心组合以及3个可能具有潜在临床价值的新组方。结论临床治疗2型糖尿病合并非酒精性脂肪性肝病的治法以“健脾行气,活血利湿”为主,使用频次最高的药物为丹参,药性多寒,药味以苦味为主,使用药物主要归脾经,挖掘结果为新处方的研发提供了一定的参考依据。Objective:To investigate TCM prescription Patterns in the treatment of type 2 diabetes mellitus(T2DM)complicated with non-alcoholic fatty liver disease(NAFLD)using the“Traditional Chinese Medicine Inheritance Support System(V2.5)”to provide novel insights for clinical treatment.Methods:Relevant literature on TCM treatments for T2DM complicated by NAFLD was retrieved from the China National Knowledge Infrastructure(CNKI),VIP Database,and WanFang Data Knowledge Service Platform,covering publications from the inception to October 31,2023.The extracted data were organized and input into the“Traditional Chinese Medicine Inheritance Support System(V2.5).”An independent database was constructed,and the data were subjected to analysis to identify the medication rule of TCM prescriptions.Results:A total of 81 prescriptions,incorporating 137 herbs,were selected.The top 10 most frequently utilized herbs included Salvia,Bupleurum,Astragalus,Crataegus,Coptis,Atractylodes,Poria,Alisma,Paeonia,and Curcuma.The herbs were predominantly cold,warm,and neutral in nature,with bitter,sweet,and pungent flavors.The most commonly targeted meridians were the spleen,liver,and stomach.Through hierarchical clustering analysis,six core herb combinations and three potentially valuable new prescriptions were identified.Conclusion:The primary therapeutic strategy for T2DM complicated by NAFLD in TCM centers on“strengthening the spleen,regulating qi,promoting blood circulation,and eliminating dampness.”Salvia emerged as the most frequently employed herb,with the majority of the herbs being cold and bitter,and the spleen meridian being the most frequently targeted.These findings offer valuable insights for the development of new therapeutic prescriptions.

关 键 词：中医药 2型糖尿病合并非酒精性脂肪性肝病 数据挖掘 用药规律 

分 类 号：R587.1[医药卫生—内分泌]