Towards in vivo photoacoustic human imaging:Shining a new light on clinical diagnostics  

作　　者：Zhiyang Wang Fei Yang Wuyu Zhang Kedi Xiong Sihua Yang 

机构地区：[1]MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science,College of Biophotonics,School of Optoelectronic Science and Engineering,South China Normal University,Guangzhou 510631,China [2]Guangdong Provincial Key Laboratory of Laser Life Science,College of Biophotonics,School of Optoelectronic Science and Engineering,South China Normal University,Guangzhou 510631,China

出　　处：《Fundamental Research》2024年第5期1314-1330,共17页自然科学基础研究（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(62335007,62305118,61822505,11774101);the Ningbo Major Research and Development Plan Project(2023Z199);the Natural Science Foundation of Guangdong Province(2022A1515010548);the Science and Technology Program of Guangzhou(2019050001;202206010094).

摘　　要：Multiscale visualization of human anatomical structures is revolutionizing clinical diagnosis and treatment.As one of the most promising clinical diagnostic techniques,photoacoustic imaging(PAI),or optoacoustic imaging,bridges the spatial-resolution gap between pure optical and ultrasonic imaging techniques,by the modes of optical illumination and acoustic detection.PAI can non-invasively capture multiple optical contrasts from the endogenous agents such as oxygenated/deoxygenated hemoglobin,lipid and melanin or a variety of exogenous specific biomarkers to reveal anatomy,function,and molecular for biological tissues in vivo,showing significant potential in clinical diagnostics.In 2001,the worldwide first clinical prototype of the photoacoustic system was used to screen breast cancer in vivo,which opened the prelude to photoacoustic clinical diagnostics.Over the past two decades,PAI has achieved monumental discoveries and applications in human imaging.Progress towards preclinical/clinical applications includes breast,skin,lymphatics,bowel,thyroid,ovarian,prostate,and brain imaging,etc.,and there is no doubt that PAI is opening new avenues to realize early diagnosis and precise treatment of human diseases.In this review,the breakthrough researches and key applications of photoacoustic human imaging in vivo are emphatically summarized,which demonstrates the technical superiorities and emerging applications of photoacoustic human imaging in clinical diagnostics,providing clinical translational orientations for the photoacoustic community and clinicians.The perspectives on potential improvements of photoacoustic human imaging are finally highlighted.

关 键 词：Photoacoustic imaging Clinical diagnostics Biomedical optics Human imaging Multiscale imaging 

分 类 号：R44[医药卫生—诊断学]