重构本草——何首乌  

Reconstruction of Chinese materia medica-fleeceflower root

作　　者：段莹莹 谢伟楠 王昭博 刘珂 张湘苑 赵锡艳[2] DUAN Yingying;XIE Weinan;WANG Zhaobo;LIU Ke;ZHANG Xiangyuan;ZHAO Xiyan(The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]西安交通大学第二附属医院,西安710004 [2]中国中医科学院广安门医院,北京100053 [3]北京中医药大学,北京100029

出　　处：《吉林中医药》2024年第11期1343-1345,共3页Jilin Journal of Chinese Medicine

基　　金：国家重点研发计划“中医药现代化”重点专项(2022YFC3502100);国家自然科学基金(82205089);中央级公益性科研院所基本科研业务费专项资金(ZZ13-YQ-030);中国中医科学院科技创新工程重大攻关项目(CI2021A01614);中国中医科学院广安门医院临床医学研究中心建设专项经费(2022LYJSZX13);中央高水平中医医院临床研究和成果转化能力提升项目—传承名老中医药专家学术经验专项(HLCMHPP2023009)。

摘　　要：通过古籍文献调研、中医药现代研究成果梳理,结合中医临床及中药学等学科领域内知名专家学者的认识及应用经验,归纳出何首乌:功效主要为解毒,消痈,截疟,润肠通便。症靶为脱发。标靶为高血脂。现代药理研究发现,何首乌及其有效成分具有生发、乌发、降血脂、抗氧化、延缓衰老、抗动脉粥样硬化、增强免疫功能等作用。由于何首乌有一定肝毒性、胃肠反应,不宜长期、大量服用,炮制后毒性可下降。何首乌临床常用剂量为3~30 g,内服时当根据不同疾病,或同一疾病不同阶段进行辨证使用,并积极探索何首乌用量与症靶、标靶量效关系构建。Through the investigation of ancient literature and the sorting of modern research achievements in traditional Chinese medicine,combined with the understanding and application experience of well-known experts and scholars in the clinical and pharmaceutical fields of traditional Chinese medicine,it is concluded that fleeceflower root mainly has the following characteristics:Its effects mainly involve removing toxicity,resolving carbuncles,preventing malaria,and moisturizing the intestines to relax bowels.Its symptom target is alopecia,while its biochemical indicator target is hyperlipidemia.Modern pharmacology has found that fleeceflower root and its active ingredients have the effects of promoting hair growth,darkening hair,lowering blood lipids,antioxidation,anti-aging,preventing atherosclerosis,and enhancing immune function.Due to certain hepatotoxicity and gastrointestinal reactions of fleeceflower root,it is not suitable for long-term or large-scale use,while its toxicity can be reduced after processing.Its clinical dosage range is 3-30g.When taken orally,it should be used according to different diseases,or different stages of the same disease,and it is advisable to explore and construct the dose-effect relationship between its dosage and its symptom targets or biochemical indicator targets.

关 键 词：何首乌 症靶 标靶 重构本草 临床回归 

分 类 号：R281.3[医药卫生—中药学]