重构本草——蒲公英  

Reconstruction of Chinese materia medica-dandelion

作　　者：马凯乐 赵旌屹 张艳娇 田传玺 金籽杉 张伟 李敏[1] MA Kaile;ZHAO Jingyi;ZHANG Yanjiao;TIAN Chuanxi;JIN Zishan;ZHANG Wei;LI Min(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;School of Basic Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]甘肃中医药大学基础医学院,兰州730000

出　　处：《吉林中医药》2024年第11期1346-1348,共3页Jilin Journal of Chinese Medicine

基　　金：中国中医科学院科技创新工程项目(CI2021A01606)。

摘　　要：通过对古籍文献调研、现代中医药研究成果梳理,结合中医临床及中药学等学科领域内专家学者的实践应用经验,综合归纳出蒲公英:主要功效为清热解毒、消肿散结、利尿通淋。症靶为乳房肿痛、胃痛、痤疮。标靶为幽门螺杆菌阳性。现代药理研究发现,蒲公英及其有效成分具有抗肿瘤、保肝、抑菌抗炎、抗氧化、增强免疫力、抗衰老、降血糖、降血脂、抗血栓、利尿等作用。蒲公英是无毒或低毒性物质,阳虚外寒及脾胃虚弱者忌用,用量过大可致缓泻。临床使用剂量为4.5~100 g,外用常用量为5~50 g,内服时需根据具体病情进行辨证施治,不同疾病或同一疾病不同阶段用量可有所调整,并积极探索蒲公英用量与症靶、标靶之间量效关系,有助于更精准的发挥药效,提升临床疗效。Based on the investigation of ancient books and literature,alongside the analysis of modern Chinese medicine research and the practical experience of experts in traditional Chinese medicine and Chinese pharmacology,it is concluded that dandelion mainly has the following characteristics:Its effects mainly involve clearing heat and detoxifying,reducing swelling and resolving nodules,and promoting diuresis and freeing strangury.Its symptom targets feature breast swelling,stomachache and acne,and its biochemical indicator target involves helicobacter pylori positive.Modern pharmacological studies have demonstrated that dandelion and its active components have the antitumor,hepatoprotective,antibacterial,anti-inflammatory,antioxidant,immune-enhancing,anti-aging,hypoglycemic,hypolipidemic,antithrombotic effects,and diuretic properties.Dandelion is considered to be non-toxic or of low toxicity.However,it should be avoided by individuals with yang deficiency,external cold,or those with weak spleen and stomach function.Excessive doses may lead to diarrhea.The internal clinical dosage typically ranges from 4.5 to 100 g,while for external applications commonly from 5 to 50g.Internal use should be based on syndrome differentiation according to patients'specific conditions.Dosage adjustments is necessary depending on different diseases,or different stages of the same disease,and it is advisable to explore the dose-effect relationship between its dosage and its symptom targets or biochemical indicator targets,which will allow for more precise therapeutic outcomes,improving clinical efficacy.

关 键 词：蒲公英 症靶 标靶 重构本草 临床回归 

分 类 号：R281.3[医药卫生—中药学]