Lysogenic phage therapy towards emerging contaminant bioremediation  

作　　者：TANG Xiang ZHOU ShunGui 

机构地区：[1]Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation,College of Resources and Environment,Fujian Agriculture and Forestry University,Fuzhou 350002,China

出　　处：《Science China(Technological Sciences)》2024年第10期3129-3131,共3页中国科学（技术科学英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.92251301,42307466);the National Key Research and Development Program of China(Grant No.2023YFD1702300);the Young Elite Scientists Sponsorship Program by CAST(Grant No.2023QNRC001).

摘　　要：Emerging contaminants often arise as by-products of technological advances,(bio)transformation products,or replacements for previously regulated chemicals.Once released into the environment,they present a significant threat to human health within the One Health framework.Among various strategies for contaminant remediation,microbial-based initiatives are particularly promising for the removal and remediation of emerging contaminants due to their environmentally friendly characteristics,such as minimal chemical use and reduced energy consumption.Although many cellular microorganisms with contaminant metabolic capabilities have been identified,bioaugmentations based on cellular microorganism face challenges.They require labor-intensive isolation or complex gene editing,and fierce competition between introduced functional microorganisms and indigenous microbes further hinders their generalization.Phages,the most abundant and diverse replicative entities in the biosphere,coexist with cellular microorganisms in almost all ecosystems.They achieve an astonishing abundance(approximately 4.8×10^(31) particles)through two basic lifecycles,traditionally classified as lytic and lysogenic.Lytic phages express auxiliary metabolic genes that redirect host metabolism toward pathways that maximize the production of new virions[1].In contrast,lysogenic phages,also known as temperate phages,can stably integrate their genomes into the host genome to form prophages during the lysogenic lifecycle.This leads to stable mutualistic behaviors due to the aligned fitness interests of lysogenic phages and their hosts[2].Lysogeny can decouple microbial taxonomic and functional composition through horizontal gene transfer(HGT).This allows the in-situ formation of new phenotypes that can circumvent competition between introduced and indigenous microbes,making lysogeny a potential candidate for emerging contaminant bioremediation.

关 键 词：mutual METABOLISM hinder 

分 类 号：X505[环境科学与工程—环境工程]