Cationic starch microparticles with integrated antibacterial and hemostatic performance  

作　　者：SU Yang NIU MengXin XU KaiDong XU Chen YANG PeiLang HU Yang XU Fu-Jian 

机构地区：[1]Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology,Ministry of Education),Beijing Laboratory of Biomedical Material,College of Materials Science and Engineering,Beijing University of Chemical Technology,Beijing 100029,China [2]Department of Burn,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

出　　处：《Science China(Technological Sciences)》2024年第10期3235-3246,共12页中国科学（技术科学英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.52173114,52221006,and 82202452);Beijing Outstanding Young Scientist Program(Grant No.BJJWZYJH012019100-10024).

摘　　要：It is urgently demanded to develop biomaterials with balanced hemostatic/antibacterial ability and facile preparation methods.In this work,cationic starch microparticles(MSQP),prepared by the facile grafting of microporous starch particles(MS)with tunable quaternized polyethyleneimine,were readily constructed as promising hemostatic materials for integrated antibacterial and hemostatic performance.The cationic grafts not only endowed MSQP with good antibacterial ability,but also benefited from biocompatible MS to achieve favorable biocompatibility.Moreover,in vitro results confirmed the superior hemostatic property of MSQP2(with the medium content of cationic grafts)among three MSQP and pristine MS.After investigating the bloodmaterial interactions of MSQP/MS,the procoagulant mechanism of MSQP2 was revealed that the optimal amount of cationic grafts achieves highly balanced plasma-protein adhesion,platelet adhesion and blood coagulation system.In vivo artery-injury model further demonstrated the superior hemostatic performance of MSQP2 for potential severe hemorrhage.This work sheds light on the design of cationic polymer-based biomaterials for balanced antibacterial and hemostatic functions.

关 键 词：HEMOSTASIS ANTIBACTERIAL cationic polymer MICROPARTICLES 

分 类 号：R318.08[医药卫生—生物医学工程] TQ317[医药卫生—基础医学]