经颅磁刺激对帕金森病患者神经炎症影响的研究进展  

Research advances in the effect of transcranial magnetic stimulation on neuroinflammation in patients with Parkinson’s disease

作　　者：韩超[1,2] 王强[2] 孟萍萍[2] 张永祥 柏广涛[2] 孙慧[2] 谢安木[1] HAN Chao;WANG Qiang;MENG Pingping;ZHANG Yongxiang;BAI Guangtao;SUN Hui;XIE Anmu(Department of Neurology,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院神经内科,山东青岛266003 [2]青岛大学附属医院康复医学科,山东青岛266003

出　　处：《精准医学杂志》2024年第6期556-559,共4页Journal of Precision Medicine

基　　金：国家自然科学基金面上项目(81971192)。

摘　　要：帕金森病(Parkinson’s disease,PD)主要的病理特征是基底神经节多巴胺能神经元丢失和路易体形成,但确切病因目前尚未明确,大量研究表明神经炎症与PD的发生发展密切相关,对炎症相关机制的研究,有助于为预防和控制PD提供新的靶点,寻找新的治疗策略。重复经颅磁刺激(rTMS)可有效改善PD患者的临床症状,减轻患者神经炎症反应,但其具体机制还需要进一步深入研究。本文总结概括了神经炎症与PD发生发展的相关性,以及rTMS对PD神经炎症的治疗作用,并对将来的研究方向进行展望。The main pathological features of Parkinson’s disease(PD)are the loss of dopaminergic neurons and the formation of Lewy bodies in the basal ganglia,but its exact etiology remained unknown.A large number of studies have shown that neuroinflammation is closely associated with the development and progression of PD,and the research on inflammation-related mechanisms may help to provide new targets for the prevention and control of PD and search for new treatment strategies.Repetitive transcranial magnetic stimulation(rTMS)can effectively improve the symptoms of PD patients and alleviate neuroinflammation,but further studies are needed to clarify its detailed mechanism.This article summarizes the association of neuroinflammation with the development and progression of PD,analyzes the role of rTMS in the treatment of neuroinflammation in PD,and proposes the future research directions.

关 键 词：帕金森病 炎症 经颅磁刺激 小神经胶质细胞 星形细胞 炎性体 适应性免疫 综述 

分 类 号：R742.5[医药卫生—神经病学与精神病学]