Aggregation-caused quenching to crystallization-induced emission transformation:hydration-induced luminescence in crystal curcumin with tunable thermochromism for in vivo tracking  

ACQ到CIE转化:水合作用诱导的姜黄素晶体发光及可调热致变色用于体内药物追踪

作　　者：Huan Shen Peng Shi Ergang Liu Yuefei Fang Shijie Xu Junbo Gong Yongzhuo Huang 申欢;石鹏;刘二刚;方月飞;许史杰;龚俊波;黄永焯(Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Zhongshan 528437,China;Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;School of Chemical Engineering and Technology,Tianjin University,Tianjin 300457,China;SINOPEC Research Institute of Petroleum Processing Co.,Ltd.,Beijing 100083,China;College of Chemical Engineering and Materials Science,Tianjin University of Science and Technology,Tianjin 300457,China;NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients,Shanghai 201203,China)

机构地区：[1]Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Zhongshan 528437,China [2]Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [3]School of Chemical Engineering and Technology,Tianjin University,Tianjin 300457,China [4]SINOPEC Research Institute of Petroleum Processing Co.,Ltd.,Beijing 100083,China [5]College of Chemical Engineering and Materials Science,Tianjin University of Science and Technology,Tianjin 300457,China [6]NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients,Shanghai 201203,China

出　　处：《Science China Materials》2024年第11期3561-3569,共9页中国科学（材料科学）（英文版）

基　　金：supported by the National Key Research and Development Program of China(2021YFE0103100,2021YFC2400600);the National Natural Science Foundation of China(NSFC)(81925035);the Department of Science and Technology of Guangdong Province(High-Level New R&D Institute 2019B090904008,High-Level Innovative Research Institute 2021B0909050003);the First Batch of Scientific and Technological Innovation Leading Talent Funding Projects in Zhongshan City(LJ2021001);the Introduced Scientific Research and Innovation Team Project in Zhongshan City(Lingnan Pharmaceutical Research and Innovation Team,CXTD2022011)。

摘　　要：The development of solid-state materials with switchable luminescence in response to stimuli remains a challenge,especially for organic materials.While crystal water significantly impacts the absorption spectra of organic crystals,it is unclear whether the emission spectra of organic luminescent materials can be systematically manipulated by water.In this study,we successfully obtained curcumin monohydrate(Form X),a channel-type hydrate exhibiting crystallization-induced emission(CIE)at 608 nm(orange fluorescence),which contrasted with the conventional forms of aggregation-caused quenching(ACQ).Thermal treatment induced the release of hydration water,resulting in a new anhydrate(Form IV)that emitted yellow-green fluorescence with the emission peak at 575 nm.Additionally,this approach can be used to track the absorption of curcumin crystals following subcutaneous or intramuscular delivery.The hydratemediated single-crystal-to-single-crystal transition(SCSC)and its associated luminescence transition were reversible and responsive to temperature,offering a green approach for synthesizing and designing aggregation-induced-emission(AIE)-based intelligent luminescent devices for detecting air humidity or drug absorption.目前固态材料在受刺激时能够切换发光性质仍然是一个挑战,特别是对于有机材料而言.晶体中的水分子极大地影响有机晶体的吸收光谱,但是否可以系统地通过水分子调控有机发光材料的发射光谱尚不清楚.在本研究中,我们成功地制备了姜黄素一水合物(X型),它是一种结晶诱导发光(CIE)的通道型水合物,在608 nm处发出橙色荧光,与传统的聚集诱导荧光猝灭(ACQ)形式有所不同.经过热处理后,姜黄素水合物释放出水分子,形成了新的无水合物(Ⅳ型),其发出黄绿色荧光,且最佳发射波长为575 nm.该方法可用于追踪皮下或肌肉注射后姜黄素晶体的吸收.水合物介导的单晶到单晶转变(SCSC)及其相关的发光转变是可逆的,并且对温度敏感,可为合成和设计基于聚集诱导发射(AIE)的智能发光装置提供一种环保的途径,也可用于检测空气湿度或示踪药物吸收.

关 键 词：CURCUMIN crystallization-induced emission channeltype hydrate single-crystal-to-single-crystal transition reversible luminescence 

分 类 号：R96[医药卫生—药理学] O657.3[医药卫生—药学]