肠道菌群代谢物三甲胺-N-氧化物与心房颤动关系的研究进展  

Research progress of intestinal flora metabolite trimethylamine N-oxide and atrial fibrillation

作　　者：徐臣年 徐登月 夏麟 于立明 王辉山 XU Chen-nian;XU Deng-yue;XIA Lin;YU Li-ming;WANG Hui-shan(Department of Cardiovascular Surgery,General Hospital of Northern Theater Command,Shenyang 110016,Liaoning,China)

机构地区：[1]中国人民解放军北部战区总医院心血管外科,辽宁沈阳110016

出　　处：《心脏杂志》2024年第5期587-591,共5页Chinese Heart Journal

基　　金：国家自然科学基金项目(81970310,82100513);中国博士后科学基金面上项目(2022M713857);辽宁省2023年中央引导地方科技发展资金项目(2023JH6/100100034);辽宁省自然科学基金面上项目(2020-MS-036);军事科技领域青年人才托举项目(18-JCJQ-QT-018)。

摘　　要：心房颤动(atrial fibrillation,AF)是一种常见的心律失常,具有高发病率和死亡率,目前其治疗取得了重大进展,其具体治疗方案上也还有很大的改进空间。治疗的关键是发现潜在的关键的基本机制,研究表明,肠道菌群代谢产物三甲胺-N-氧化物(trimethylamine N-oxide,TMAO)在心律失常等心血管疾病中起重要作用,并可作为预后生物标志物。TMAO与AF的发生、进展、复发和栓塞风险相关。本文首先回顾了与AF临床特征相关的基本电生理机制,AF发病中TAMO的潜在作用机制,同时对TMAO及相关信号通路可能成为AF的潜在治疗靶点进行探讨。此外,对于高TMAO的AF患者,未来的个体化干预措施的意义进行展望。Atrial fibrillation(AF)is a common arrhythmia with high incidence rate and mortality.At present,significant progress has been made in its treatment,and there is still much room for improvement in its specific treatment plan.The key to treatment is to discover the underlying key basic mechanism.Research shows that trimethylamine N-oxide(TMAO),a metabolite of intestinal flora,plays an important role in cardiovascular diseases such as arrhythmia,and can be used as a prognostic biomarker.TMAO is associated with the occurrence,progression,recurrence and risk of embolism of atrial fibrillation(AF).In this paper,we first reviewed the basic electrophysiological mechanisms related to the clinical features of AF,and the potential mechanisms of TAMO in the pathogenesis of AF.At the same time,we discussed that TMAO and related signal pathways may become potential therapeutic targets of AF.In addition,for AF patients with high TMAO,the significance of individualized interventions in the future was prospected.

关 键 词：三甲胺-N-氧化物 TMAO 房颤 心律失常 肠道菌群. 

分 类 号：R580[医药卫生—内分泌]