Mediating role of inflammatory indicators in the association between sleep status and blood pressure in centenarians:evidence from China Hainan Centenarian Cohort Study  

作　　者：Qiao LI Sheng-Shu WANG Guang-Dong LIU Jian-Hua WANG Ya-Li ZHAO Miao LIU Yao HE Shan-Shan YANG 

机构地区：[1]Jockey Club School of Public Health and Primary Care,The Chinese University of Hong Kong,Hong Kong,China [2]Institute of Geriatrics,Beijing Key Laboratory of Aging and Geriatrics,National Clinical Research Center for Geriatrics Diseases,Second Medical Center,Chinese PLA General Hospital,Beijing,China [3]Graduate School,Chinese PLA General Hospital,Beijing,China [4]Central Laboratory of Hainan Hospital,Chinese PLA General Hospital,Sanya,China [5]Department of Disease Prevention and Control,First Medical Center,Chinese PLA General Hospital,Beijing,China

出　　处：《Journal of Geriatric Cardiology》2024年第9期874-883,共10页老年心脏病学杂志（英文版）

摘　　要：Objectives To conduct a comprehensive analysis in Hainan centenarians on the link between sleep status and their blood pressure status.Furthermore,the study also aims to explore how inflammatory indicators may mediate the relationship.Methods The China Hainan Centenarians Cohort Study(CHCCS)collected baseline data on sleep status,inflammatory indicators,and blood pressure data.The study used a mediation model to investigate how inflammatory indicators mediate the relationship between sleep status and blood pressure status.Result In this study,a total of 967 centenarians were included.The prevalence of hypertension among the centenarians was 71.4%.The analysis showed that centenarians with poor sleep quality had a 43%higher risk of hypertension compared to those with normal sleep quality(OR=1.43,95%CI:1.03-1.97).Additionally,centenarians with nighttime sleep durations of≤6 h or>9 h had higher proportions of high pulse pressure(PP),with OR values of 1.76(95%CI:1.18-2.63)and 2.07(95%CI:1.34-3.19),respectively.Mediation analysis illustrated that complement C3 played a mediating role in the relationship between sleep quality and hypertension,with an effect ratio of 2.4%.Similarly,lymphocyte count,the neutrophil-to-lymphocyte ratio(NLR),and the systemic immune-inflammation index(SII)were identified as mediating factors in the association between nighttime sleep duration and high PP,with effect ratios of 91.22%,36.93%,and 0.20%,respectively.Conclusion In centenarians,poor sleep quality raises the risk of hypertension,with complement C3 as a mediator.Additionally,nighttime sleep durations of≤6 h or>9 h increases the risk of high PP,mediated by lymphocyte count,NLR,and SII.

关 键 词：SLEEP hypertension inflammation 

分 类 号：R544.1[医药卫生—心血管疾病]