2018~2023年男性HPV感染状况及基因型分布研究  

Research on the prevalence and genotype distribution of HPV among male from 2018 to 2023

作　　者：杨桂茂 张晓梦 刘蒙蒙 YANG Guimao;ZHANG Xiaomeng;LIU Mengmeng(Department of Clinical Laboratory,Affiliated Hospital of Shandong Second Medical University,Weifang 261031,China)

机构地区：[1]山东第二医科大学附属医院检验科,山东潍坊261031

出　　处：《山东第二医科大学学报》2024年第4期272-276,共5页Journal of Shandong Second Medical University

基　　金：山东省自然科学基金青年项目(项目编号:ZR2023QH061);2023年度潍坊市卫健委科研项目计划(项目编号:WFWSJK-2023-062);潍坊医学院附属医院博士科研启动基金资助项目(项目编号:2021BKQD4)。

摘　　要：目的统计分析潍坊地区男性人群感染人乳头瘤病毒(HPV)的基因亚型分布和流行病学特征。方法回顾性分析2018年1月~2023年12月在我院做HPV分型检测的661例男性的检测数据。采用实时荧光定量PCR方法测定23种HPV基因亚型,并分析HPV各亚型占比、HPV阳性患者的年龄分布以及2018~2023年阳性率变化情况。结果661例样本中检测出HPV阳性257例,总阳性率38。88%。在阳性样本中,单纯低危亚型占比41.25%,单纯高危亚型占比30。35%,高、低危亚型混合感染占比28.40%。低危型以6、11、43亚型感染最常见,高危型以16、58、52亚型感染最常见。各年龄组均以单一亚型感染为主,其次为双重亚型感染。<20岁的年龄组感染率最高(70.37%),但是阳性感染者高峰年龄段主要集中在20~40岁。相比较于2018年的感染率(64。43%),2019~2023年每年的感染率明显下降,2023年感染率最低(27.81%),但是2023年总检测人数最多。结论山东省潍坊地区男性HPV感染者以单一低危亚型感染较常见,总体感染基因型以6、11、43、16、58、42亚型最常见。2018~2023年阳性率逐年下降,年度百分比变化(APC)呈现下降趋势。2020年新型冠状病毒(COV-ID-19)流行期间,男性HPV检测者数量减少,HPV感染率下降。Objective To analyze the genotype distribution and epidemiological characteristics of human papilloma virus(HPV)in male patients in Wei fang city.Methods The data of 661 patients who were performed detec-tions of HPV DNA from January 2018 to December 2023 was collected and analyzed.Twenty three gene types of HPV were tested by Real-time Quantitative PCR,and the proportion of HPV gene types,age distribution and annual positive rate were analyzed.Results A total of 257 positive cases were detected from 661 samples of male,with a total positive rate of 38.88%.Among these positive samples,41.25%were infected with single low-risk HPV(LR-HPV),30.35%were infected with single high-risk HPV(HR-HPV),and 28.40%were infected with high and low risk HPV.LR-HPV were most commonly infected with genotypes 6,11 and 43,and HR-HPV were most commonly infected with subtypes 16,58 and 52.Single infection was domination in all age group,followed by double infections.The highest prevalence of infection was found in the age group less than 20 years(70.37%),but the peak age group of positive infections was mainly concentrated in the age group of 20~40 years.Compared to the infection rate in 2018(64.43%),the annual infection rate decreased significantly from 2019 to 2023,with the lowest rate in 2023(27.81%),but the total number of people tested in 2023 is the largest.Conclusion The LR-HPV infection was more common among males in Wei fang area,and the gene types 6,11,43,16,58 and 42 were the most common.During COVID-19 pandemic,fewer men were tested for HPV and the HPV infection rate has decreased dramatically.

关 键 词：人乳头瘤病毒 男性 基因亚型分布 阳性率 

分 类 号：R373[医药卫生—病原生物学]