急性心肌梗死合并慢阻肺伴肺部感染患者三维斑点追踪技术及血清因子评估价值分析  

Evaluation value of 3D dot tracking technique and serum TNF-α,Ang-2 and CCL-21 in patients with AMI complicated with COPD and pulmonary infection

作　　者：刘伟亮[1] 陆海永 郑英娟[1] 孙晨曦 张敏秀 LIU Weiliang;LU Haiyong;ZHENG Yingjuan;SUN Chenxi;ZHANG Minxiu(Department of Ultrasound Medicine,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei,China)

机构地区：[1]河北北方学院附属第一医院超声医学科,河北张家口075000

出　　处：《中国病原生物学杂志》2024年第12期1397-1403,共7页Journal of Pathogen Biology

基　　金：河北省卫生健康委科研基金项目(No.20211388)。

摘　　要：目的 本研究旨在探讨三维斑点追踪技术(3D-STE)结合血清中肿瘤坏死因子-α(TNF-α)、血管生成素-2(Ang-2)及C-C趋化因子配体21(CCL-21)水平在评估急性心肌梗死(AMI)合并慢性阻塞性肺疾病(COPD)伴肺部感染患者中的临床应用价值。方法 研究选取了2021年1月至2024年1月期间,本院收治的120例患者,根据疾病状态分为三组:研究组(30例,AMI合并COPD伴肺部感染,接受标准治疗并联合3D-STE监测心肌形变参数及血清TNF-α、Ang-2、CCL-21水平评估)、对照组(30例,相同疾病状态,仅接受标准治疗)、健康对照组(30例,健康体检者,无相关疾病史)。通过对比分析治疗前后研究组与对照组患者的心肌形变参数及血清因子水平变化,评估其疗效及预后。结果 研究结果显示,研究组患者在接受联合治疗后,心肌形变参数显著改善,同时血清TNF-α、Ang-2、CCL-21水平显著下降,表明心肌功能得到有效恢复。相比之下,对照组患者在仅接受标准治疗后,虽然心肌形变参数及血清生化指标有所提升,但改善程度显著低于研究组。进一步分析发现,研究组中心肌形变参数的改善与血清TNF-α、Ang-2、CCL-21水平的下降之间存在显著相关性。结论 三维斑点追踪技术结合血清TNF-α、Ang-2、CCL-21水平评估在AMI合并COPD伴肺部感染患者的疗效评估中具有重要参考价值。这些指标不仅能够全面反映患者的心肌功能、炎症反应及血管生成状态,还为临床治疗方案的选择及疗效评估提供了科学依据。Objective The purpose of this study was to investigate the clinical application of three-dimensional spot tracking technology(3D-STE)combined with serum levels of tumor necrosis factor-α(TNF-α),angipoietin-2(Ang-2)and C-C chemokine ligand 21(CCL-21)in the evaluation of patients with acute myocardial infarction(AMI)complicated with chronic obstructive pulmonary disease(COPD)and pulmonary infection.MethodssA total of 120 patients admitted to our hospital from January 2021 to January 2024 were selected and divided into three groups according to their disease status:study group(30 patients,AMI complicated with COPD and pulmonary infection,who received standard treatment and combined with 3D-STE to monitor myocardial deformation parameters and serum TNF-α,Ang-2,and CCL-21 levels),control group(30 cases,same disease state,only standard treatment),healthy control group(30 cases,healthy physical examination patients,No history of associated disease).The changes of myocardial deformation parameters and serum factor levels between the study group and the control group before and after treatment were compared and analyzed to evaluate their efficacy and prognosis.Results The results showed that the myocardial deformation parameters and serum levels of TNF-α,Ang-2 and CCL-21 were significantly reduced after the combined therapy,indicating that the myocardial function was effectively restored.In contrast,although the myocardial deformation parameters and serum biochemical indexes were improved in the control group after receiving only standard treatment,the degree of improvement was significantly lower than that in the study group.Further analysis showed that there was a significant correlation between the improvement of central muscle deformation parameters and the decrease of serum levels of TNF-α,Ang-2 and CCL-21 in the study group.ConclusionTThree-dimensional spot tracking technology combined with serum TNF-α,Ang-2 and CCL-21 levels is an important reference value in the evaluation of the efficacy of patients with AM

关 键 词：急性心肌梗死(AMI) 慢性阻塞性肺疾病 肺部感染 三维斑点追踪技术(3D-STE) 心肌形变参数 

分 类 号：R542.22[医药卫生—心血管疾病] R563[医药卫生—内科学] R446.1[医药卫生—临床医学]