铁代谢相关蛋白在昆虫抗药性中作用的研究进展  

Research progress on the role of iron metabolism-related proteins in insect resistance to insecticides

作　　者：秦浩然 赵梦冉 王靖 臧文婧 吴依苹 邢路家 王雪 谭文彬 QIN Haoran;ZHAO Mengran;WANG Jing;ZANG Wenjing;WU Yiping;XING Lujia;WANG Xue;TAN Wenbin(School of Medical Engineering,Jining Medical University,Jining 273507,Shandong,China)

机构地区：[1]济宁医学院医药工程学院,山东济宁273507

出　　处：《中国病原生物学杂志》2024年第12期1525-1528,共4页Journal of Pathogen Biology

基　　金：济宁医学院大学生创新训练计划项目(No.cx2013019z)。

摘　　要：全球昆虫抗药性问题严重影响虫媒病的防制。铁代谢通路中相关蛋白通过调节细胞铁摄取、避免铁毒性、维持铁平衡和保持细胞稳态在昆虫对杀虫剂抗药制中发挥作用。本文从节肢动物及昆虫的种属分类、危害、控制种群的方法、杀虫剂种类及抗性机制、铁代谢通道与细胞生存的关系、铁代谢各种蛋白在昆虫抗药性中的作用等方面进行讨论,为杀虫剂抗性检测及机制研究、昆虫治理及虫媒病防治提供思路。The global problem of insect resistance to insecticides seriously affects the prevention and control of insect borne diseases.Proteins related to the iron metabolism pathway play a role in insect resistance to insecticides by regulating cellular iron uptake,avoiding iron toxicity,maintaining iron balance,and maintaining cellular homeostasis.This article discusses the species classification,hazards,population control methods,insecticide types and resistance mechanisms of arthropods and insects,the relationship between iron metabolism channels and cell survival,and the role of various iron metabolism proteins in insect resistance.It provides ideas for insecticide resistance detection and mechanism research,insect management,and prevention and control of vector borne diseases.

关 键 词：昆虫 铁代谢蛋白 杀虫剂 抗性机制 综述 

分 类 号：R384[医药卫生—医学寄生虫学]