蛋白质组学在脊柱相关疾病研究的现状  

Current status of proteomics in the research of related spine diseases

作　　者：卜献忠 卜保献 钟远鸣[4] 麦威 BU Xian-zhong;BU Bao-xian;ZHONG Yuan-ming;MAI Wei(First Department of Orthopaedics,First Affiliated Hospital,Henan University of Chinese Medicine,Zhengzhou 450000,China;Guangxi University of Chinese Medicine,Nanning 530001,China;Luoyang Zhenggu Hospital of Henan Province,Luoyang 471002,China;First Affiliated Hospital,Guangxi University of Chinese Medicine,Nanning 530023,China)

机构地区：[1]河南中医药大学第一附属医院骨伤一科,河南郑州450000 [2]广西中医药大学,广西南宁530001 [3]河南省洛阳正骨医院(河南省骨科医院),河南洛阳471002 [4]广西中医药大学第一附属医院,广西南宁530023

出　　处：《中国矫形外科杂志》2024年第20期1858-1863,共6页Orthopedic Journal of China

基　　金：国家自然科学基金-青年基金(编号:82405439);河南中医药大学博士启动基金项目(编号:KY-B0367-36);国家自然科学基金项目(编号:81760874,82260942);广西科技计划项目(编号:桂科AB20159018);广西中医药重点学科建设项目(编号:GZXK-Z-20-21);河南省中医药科学研究专项课题项目(编号:20-21ZY2083,2023ZXZX1003);广西研究生教育创新计划资助项目(编号:YCBXJ2021009);洛阳市2022-2024年度中医重点学科项目(中西医结合医学-脊柱外科)。

摘　　要：目前蛋白质组学技术大致可分为双向电泳技术、生物质谱技术、液质联用技术等,其具备快速筛选及鉴定疾病的特异性生物标记物的优点,可以从蛋白质水平角度对机体内各种生理变化、病理转变过程进行全面的认识。目前蛋白质组学技术在医学领域得到广泛应用。本文就其在脊柱相关疾病中的应用现状进行综述,包括椎间盘退变(intervertebral disc degeneration,IDD)、脊髓损伤(spinal cord injury,SCI)发生与修复机制研究以及脊柱韧带骨化与肥厚、颈椎病(cervical spondylosis,CS)、强直性脊柱炎(ankylosing spondylitis,AS)、脊柱侧弯、脊柱结核(spinal tuberculosis,STB)、神经管缺陷(neural tube defects,NTDs)生物标记物筛选和发生机制研究等。With rise and rapid development of proteomics technology,this technology provides an overall and comprehensive understanding of various physiological and pathological changes in the body from the perspective of protein level due to its advantages of rapidscreening and identification of specific biomarkers of diseases.At present,proteomics technology has been widely used in the medical field.This article reviews the current status of its application in related spinal diseases,including intervertebral disc degeneration(IDD),spinalcord injury focused on the pathogenesis and repair mechanism,as well as spinal ligament ossification and hypertrophy,cervical spondylosis(CS),ankylosing spondylitis(AS),scoliosis,spinal tuberculosis(STB),neural tube defects(NTDs)biomarker screening and pathogenesis research.

关 键 词：蛋白质组学 脊柱疾病 发生机制 生物标记物 修复机制 

分 类 号：R318[医药卫生—生物医学工程]