质谱成像技术在环境领域的应用  

Application of the mass spectrometry imaging technology in environmental field

作　　者：张玉林 周杨浩 陈忠礼[1,2] 陈瑞煌 邵迎 ZHANG Yu-lin;ZHOU Yang-hao;CHEN Zhong-li;CHEN Rui-huang;SHAO Ying(College of Environment and Ecology,Chongqing University,Chongqing 400044,China;Key Laboratory of Eco-environments in Three Gorges Reservoir Region,Ministry of Education,Chongqing 400044,China)

机构地区：[1]重庆大学环境与生态学院,重庆400044 [2]三峡库区生态环境教育部重点实验室,重庆400044

出　　处：《中国环境科学》2024年第11期6408-6417,共10页China Environmental Science

基　　金：国家自然科学基金青年基金资助项目(51909015)。

摘　　要：本文通过文献收集、研读及Citespace文献计量分析,综述了质谱成像(MSI)技术的发展历程及其在环境领域最新应用现状,并结合目前环境领域所面临的研究瓶颈,对MSI的发展前景进行了探讨.研究表明,MSI作为一种集高灵敏度质谱分析和高精度空间分辨率成像于一体的新技术,可直接从样品表面采集和鉴定分子信息.在环境毒理学与监测研究领域,一方面通过MSI可实现对污染物及其转化产物在环境介质或生物体组织内部、细胞乃至亚细胞上的分布定位与物质定量,揭示污染物的致毒靶位;另一方面,解析污染物的生物累积、生物转化、代谢活化特征与机制.综上所述,MSI在环境领域的应用具有重要的科学意义,在水、大气和土壤污染监测,尤其是污染物原位检测与毒性效应解析等领域提供新的视角,为污染物风险筛查评估与管控提供科学依据.Through literature collection,study and bibliometric analysis of Citespace literature,this paper summarizes the development history of mass spectrometry imaging(MSI)technology and its latest application status in the environmental field.Combined with the current research bottleneck in the environmental field,the development prospect of MSI is deeply discussed.MSI,as a new technology integrating high sensitivity mass spectrometry and high precision spatial resolution imaging,can directly collect and identify molecular information from the sample.In the field of environmental toxicology and monitoring,MSI,on one hand,can demonstrate the distribution,location and quantify the pollutants and their transformed products in environmental media or within biological tissues,cells and even sub-cells,and thus reveal the target of pollutant action.On the other hand,it can analyse the characteristics and mechanisms of pollutants'bioaccumulation,biotransformation and metabolic activation.In summary,the application of MSI in the environmental field has important scientific significance,providing a new perspective in the monitoring of water,air and soil pollution,particularly for in situ identification of pollutants and analysis of their toxic effects.Besides,it provides a scientific basis for the risk screening,assessment and control of pollutants.

关 键 词：质谱成像 环境毒理 环境监测 污染物分布 毒性机制解析 

分 类 号：X830.2[环境科学与工程—环境工程]