普瑞巴林联合氨酚曲马多对肺结节穿刺定位术患者急性疼痛的影响  

Effect of pregabalin combined with tramadol/acetaminophen on acute pain in patients undergoing CT⁃guided puncture local⁃ization of pulmonary nodules

作　　者：王清峰 刘泓妍 张丽 刘郁鋆 徐祗彪 赵林林 Wang Qingfeng;Liu Hongyan;Zhang Li;Liu Yuyun;Xu Zhibiao;Zhao Linlin(School of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China;Department of Anesthesiology,the Second Affiliated Hos-pital of Nantong University,Nantong 226000,China;Department of Anesthesiology,the First People's Hospital of Nantong,Nantong 226000,China;Department of Anesthesiology,the Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,China;Jiangsu Provincial Key Laboratory of Anesthesia and Analgesia Application Technology of Xuzhou Medical University,Xuzhou 221004,China)

机构地区：[1]徐州医科大学麻醉学院,徐州221004 [2]南通大学第二附属医院麻醉科,南通226000 [3]南通市第一人民医院麻醉科,南通226000 [4]徐州医科大学附属医院麻醉科,徐州221002 [5]徐州医科大学江苏省麻醉与镇痛应用技术重点实验室,徐州221004

出　　处：《国际麻醉学与复苏杂志》2024年第9期962-969,共8页International Journal of Anesthesiology and Resuscitation

摘　　要：目的探讨普瑞巴林和氨酚曲马多对CT引导下肺结节穿刺定位术患者急性疼痛的影响。方法采用2×2析因试验设计,选取120例择期行CT引导下肺结节穿刺定位术的患者,采用随机数字表法将患者随机分为4组:对照组(C组,30例)、普瑞巴林复合安慰剂组(PC组,29例)、氨酚曲马多复合安慰剂组(AC组,30例)、普瑞巴林复合氨酚曲马多组(PA组,29例)。各组均于定位前1h口服相应药物。分析普瑞巴林与氨酚曲马多之间是否存在交互作用(若存在交互作用,则分析普瑞巴林和氨酚曲马多各自的单独效应;若不存在交互作用,则分析普瑞巴林和氨酚曲马多各自的主效应)。若分析普瑞巴林的主效应,患者则分为普瑞巴林组(58例)与非普瑞巴林组(60例);若分析氨酚曲马多的主效应,患者则分为氨酚曲马多组(59例)与非氨酚曲马多组(59例)。记录患者一般资料和穿刺定位相关资料。采用数字分级评分法(NumericalRatingScale,NRS)评估所有患者的疼痛评分,记录定位后即刻收缩压、即刻舒张压、即刻心率、即刻脉搏血氧饱和度,记录中重度疼痛发生率、镇痛补救比例、药物不良反应发生率、患者满意度(非常满意、满意、一般、不满意、非常不满意)、定位前后收缩压差值、定位前后舒张压差值和定位前后心率差值。结果患者一般资料和穿刺定位相关资料差异均无统计学意义(均P>0.05)。普瑞巴林与氨酚曲马多的主效应均显著(P<0.05),但两者交互作用不显著(P=0.752)。与非普瑞巴林组比较,普瑞巴林组患者NRS评分、定位后即刻收缩压、定位后即刻舒张压、定位后即刻心率、中重度疼痛发生率、镇痛补救比例均较低(均P<0.05),定位后即刻脉搏血氧饱和度及非常满意的人数均较高(均P<0.05),而药物不良反应发生率差异无统计学意义(P>0.05)。与非氨酚曲马多组比较,氨酚曲马多组患者NRS评分、定位后即刻收缩压、Objective To investigate the effect of pregabalin combined with tramadol/acetaminophen on acute pain in pa-tients undergoing CT-guided puncture localization of pulmonary nodules.Methods A 2×2 factorial trial design was used,and 120 patients scheduled for CT-guided puncture localization of pulmonary nodules were selected.According to the random number table method,the patients were divided into four groups:a control group(group C,n=30),a pregabalin plus placebo group(group PC,n=29),a tramadol/acetaminophen plus placebo group(group AC,n=30),and a pregabalin plus tramadol/acetaminophen group(group PA,n=29).Each group received the corresponding oral medication 1 h before localization.Whether there was an interaction between pregaba-lin and tramadol/acetaminophen would be analyzed(If there was an interaction,the individual effects of pregabalin and tramadol/acet-aminophen would be analyzed.If there was no interaction,the primary effects of pregabalin and tramadol/acetaminophen would be ana-lyzed).For analysis of the primary effect of pregabalin,the patients were divided into a pregabalin group(n=58)and a non-pregabalin group(n=60).For analysis of the primary effect of tramadol/acetaminophen,the patients were divided into a tramadol/acetaminophen group(n=59)and a non-tramadol/acetaminophen group(n=59).The general data and the related data of puncture localization of pa-tients were recorded.The Numerical Rating Scale(NRS)was used to assess pain scores in all patients.Then,the systolic blood pres-sure,diastolic blood pressure,heart rate,and pulse oxygen saturation immediately after localization,the incidence of moderate to se-vere pain,the proportion of rescue analgesia,the incidence of adverse drug reactions,patient satisfaction(very satisfied,satisfied,aver-age,dissatisfied,and very dissatisfied),and the differences in systolic blood pressure,diastolic blood pressure,and heart rate before and after localization were recorded.Results There was no statistical difference in the general data and the related data of punctu

关 键 词：肺结节 穿刺定位 急性疼痛 普瑞巴林 氨酚曲马多 

分 类 号：R614[医药卫生—麻醉学]