血清泌乳素、FSH及AMH水平与多囊卵巢综合征不孕女性卵巢储备功能的关系  

Correlation of Serum Prolactin,FSH and AMH Levels with Ovarian Reserve Function in Infertile Women with Polycystic Ovary Syndrome

作　　者：李洁[1] Li Jie(The First People's Hospital of Shangqiu Shangqiu,Henan 476000,China)

机构地区：[1]商丘市第一人民医院,河南商丘476000

出　　处：《辽宁医学杂志》2024年第5期62-65,共4页Medical Journal of Liaoning

摘　　要：目的 探讨血清泌乳素、促卵泡生成素(follicle stimulating hormone, FSH)及抗缪勒管激素(anti mullerian hormone, AMH)水平与多囊卵巢综合征不孕女性卵巢储备功能的关系。方法 选取2022年5月至2023年2月在本院收治的80例多囊卵巢综合征不孕女性患者作为研究对象为研究组,选取78例纳入健康标准的同期体检且未孕者作为对照组,比较研究组与对照组中的血清泌乳素、FSH及AMH水平、比较研究组中不同卵巢储备功能患者的血清泌乳素、FSH及AMH水平、评估各项指标对多囊卵巢综合征不孕女性卵巢储备功能的诊断价值。结果 研究组血清泌乳素、FSH和AMH表达水平显著高于对照组,差异具有统计学意义(P<0.05);研究组中卵巢储备功能低反应患者血清泌乳素水平高于卵巢储备功能正常反应患者、低反应患者FSH水平高于正常反应患者、低反应患者AMH水平高于正常反应患者,差异具有统计学意义(P<0.05);使用连续性变量相关性pearson分析得出泌乳素、FSH和AMH水平与卵巢储备功能障碍的严重程度呈正相关(P<0.05);ROC曲线分析显示,当泌乳素、FSH、AMH的AUC分别为0.733、0.782、0.765时,约登指数最大,其截断值分别为18.63、8.93、6.45时,联合诊断AUC为0.903(95%CI:0.865~0.950)、灵敏度77.5、阳性预测值87.1、阴性预测值79.7(P<0.05),综合诊断效能最佳。结论 血清泌乳素、FSH及AMH水平与多囊卵巢综合征不孕患者卵巢储备功能密切相关,且三者联合诊断效能最佳。Objective To discuss the correlation of serum prolactin,follicle stimulating hormone(FSH)and anti mul-lerian hormone(AMH)levels with ovarian reserve function in infertile women with polycystic ovary syndrome(PCOS).Methods Eighty infertile female patients with PCOS admitted to our hospital from May 2022 to February 2023 were select-ed as study group,and another 78 healthy infertile female were concurrently selected as control group.Serum prolactin,FSH and AMH levels were compared between two groups,and the three indicators of infertile women with different ovarian re-serve function were also compared.Then the diagnostic value of various indexes for ovarian reserve function in infertile women with PCOS was evaluated.Results The serum expression levels of prolactin,FSH and AMH were significantly high-er than those of the control group,the difference was statistically significant(P<0.05);in the study group,patients with low ovarian reserve function were higher than normal ovarian reserve patients,low response patients had higher FSH levels than normal response patients,low response patients had higher AMH levels(P<0.05);by pearson analysis,prolactin,FSH and AMH levels were positively correlated with the severity of ovarian reserve dysfunction(P<0.05).ROC curve a-nalysis showed that when the AUC was 0.733,0.782,0.765,respectively,the largest,with the cutoff value of 18.63,8.93,6.45,respectively,the combined diagnosis AUC was 0.903(95%CI:0.865~0.950),sensitivity77.5,positive predictive value 87.1,negative predictive value 79.7(P<0.05),the best comprehensive diagnostic efficacy.Conclusion Serum prolactin,FSH,and AMH are closely related to ovarian reserve function in infertile patients with PCOS,and the combined test of the three has the best diagnostic efficacy.

关 键 词：泌乳素 FSH AMH 多囊卵巢综合征不孕 卵巢储备功能 

分 类 号：R711.6[医药卫生—妇产科学]