儿童炎症性肠病发病机制及血清生物标志物研究进展  

Progress on pathogenesis and serum biomarkers of inflammatory bowel disease in children

作　　者：许晓红 吴捷 Xu Xiaohong;Wu Jie(Department of Gastroenterology,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心、首都医科大学附属北京儿童医院消化科,100045

出　　处：《国际儿科学杂志》2024年第9期577-581,共5页International Journal of Pediatrics

基　　金：国家重点研发计划(2023YFC2706503)。

摘　　要：儿童炎症性肠病(inflammatory bowel disease,IBD)属于儿童消化系统疾病,是一种以肠道为主要累及部位的慢性复发性疾病。虽然IBD的发病机制仍未明确,但是研究显示,IBD的发病涉及个体的遗传易感性、肠道菌群异常以及免疫应答反应之间的复杂相互作用,这些因素给IBD的预防及治疗带来了较大困难。因此,对儿童IBD的发病机制、血清生物标志物进行探讨非常重要,可为临床医生早期诊断及治疗该病提供参考依据。该文根据国内外关于IBD的相关报道,对儿童IBD发病机制及血清生物标志物展开综述,旨在为临床更早、更有效地防治儿童IBD提供可靠性理论参考。Inflammatory bowel disease(IBD)in children is a digestive system disease,which is a chronic recurrent disease mainly involving the intestinal tract.Although the pathogenesis of IBD is still unknown,studies have shown that the pathogenesis of IBD involves complex interactions between individual genetic susceptibility,abnormal intestinal flora,and immune response,which make the prevention and treatment of IBD difficult.Therefore,it is very important to explore the pathogenesis and serum biomarkers of paediatric IBD,which can provide a reference basis for clinicians to make early diagnosis and treatment of this disease.This paper reviews the pathogenesis and serum biomarkers of paediatric IBD through domestic and international reports on IBD,with the aim of providing reliable theoretical guidance for earlier and more effective prevention and treatment of paediatric IBD in clinical practice.

关 键 词：儿童 炎症性肠病 克罗恩病 溃疡性结肠炎 发病机制 血清生物标志物 

分 类 号：R725.7[医药卫生—儿科]