骨质疏松症蛋白质组学研究进展  

Progress of proteomics in osteoporosis

作　　者：林小云 李梅 LIN Xiao-yun;LI Mei(Department of Endocrinology,Key Laboratory of Endocrinology of National Health Commission,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院、北京协和医学院、北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室,北京100730

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2024年第5期491-497,共7页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家重点研发计划(2021YFC2501700);国家自然科学基金面上项目(82070908、82370894);中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-051);中央高水平医院临床科研业务费“专科提升项目”资助(2022-PUMCH-B-014)。

摘　　要：骨质疏松症是与增龄相关、患病率高、危害严重的骨骼疾病,其关键发病机制是骨重建失衡,目前对骨重建失衡导致骨质疏松症的分子机制知之甚少。近年来,多种基于蛋白质组学的分析方法在骨质疏松症研究领域被广泛应用,这些分析聚焦于不同的生物样本,包括血浆、单核细胞、骨髓、骨组织及外泌体等,在探索骨质疏松症分子机制、生物标志物和治疗靶点方面展现出重要价值。本文旨在综述骨质疏松症蛋白质组学研究的新进展,以期为骨质疏松症的分子调控机制和治疗靶点研究提供思路。Osteoporosis is an aging-related bone disease with high prevalence and severe health risks.The key pathogenesis of osteoporosis is the imbalance of bone remodeling.However,the in-depth molecular mechanism of bone remodeling imbalance is still poorly understood.In recent years,various proteomics-based analytical methods have been widely applied in osteoporosis research.These analyses focus on different biological samples,including plasma,mononuclear cells,bone marrow,bone tissue and exosomes,demonstrating significant value in exploring the molecular mechanisms,biomarkers,and therapeutic targets of osteoporosis.In this article,the recent progress of proteomic research in osteoporosis was reviewed in order to provide ideas for the study of molecular regulatory mechanisms and therapeutic targets of osteoporosis.

关 键 词：骨质疏松症 蛋白质组学 成骨细胞 破骨细胞 

分 类 号：R589.5[医药卫生—内分泌]