肠道微生物介导免疫系统影响骨代谢  

Gut microbiota mediating the immune system to affect bone metabolism

作　　者：叶灵山 华臻[2] 李绍烁 孟晓辉 王建伟[1] YE Ling-shan;HUA Zhen;LI Shao-shuo;MENG Xiao-hui;WANG Jian-wei(Department of Orthopedics and Traumatology of Traditional Chinese Medicine,Nanjing University of Chinese Medicine Wuxi Affiliated Hospital,Nanjing 210023,China;Joint Orthopedics Ward,Department of Orthopedics and Traumatology,Nanjing University of Chinese Medicine Wuxi Affiliated Hospital,Jiangsu Chinese Medicine Clinical Innovation Center of Degenerative Bone and Joint Disease,Wuxi 214071,Jiangsu,China)

机构地区：[1]南京中医药大学无锡附院中医骨伤科学系,南京210023 [2]南京中医药大学无锡附院骨伤科关节骨科,江苏省中医退行性骨关节病临床医学创新中心,江苏无锡214071

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2024年第5期524-532,共9页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家自然科学基金面上项目(82274546);国家自然科学基金青年项目(82205142);无锡市“双百”中青年医疗卫生拔尖人才(HB2020063)。

摘　　要：近期研究发现,肠道微生物(gut microbiota,GM)可通过调控宿主代谢水平、内分泌及免疫系统等途径影响骨质疏松症(osteoporosis,OP)。其中,GM及其代谢产物通过影响免疫细胞发育分化或介导免疫过程相关信号通路调控骨代谢是重要一环。本文总结GM通过影响宿主免疫系统在OP进程中发挥作用的途径,以期为未来预防或治疗OP提供新思路。Gut microbiota(GM)plays a key role in regulating various physiological and pathological processes related to human health.Recent studies have found that GM can affect osteoporosis(OP)by regulating the host metabolic level,endocrine and immune systems.Among them,GM and its metabolites play an important role in regulating bone metabolism by influencing immune cell development and differentiation or mediating immune process-related signaling pathways.This article summarized the ways GM acting in the process of OP by influencing the host immune system,in order to provide new ideas for the prevention or treatment of OP in the future.

关 键 词：肠道微生物 免疫系统 骨代谢 骨质疏松症 

分 类 号：R681[医药卫生—骨科学] R593[医药卫生—外科学]