丹红注射液联合双抗疗法治疗恶性肿瘤并急性脑梗死疗效观察  

Clinical observation on Danhong Injection combined with bispecific antibody therapy in treatment of malignant tumors and acute cerebral infarction

作　　者：王小燕 何文静 李海云 高钟生 王丽敏 WANG Xiao-yan;HE Wen-jing;LI Hai-yun;GAO Zhong-sheng;WANG Li-min(Zhangjiakou First Hospital,Zhangjiakou 075000)

机构地区：[1]河北省张家口市第一医院,河北张家口075000

出　　处：《湖北中医药大学学报》2024年第5期18-21,共4页Journal of Hubei University of Chinese Medicine

基　　金：河北省张家口市重点研发计划项目(项目编号:2121107D)。

摘　　要：目的观察丹红注射液联合双抗疗法治疗恶性肿瘤并急性脑梗死(MACI)临床疗效。方法将我院100例MACI患者随机分为对照组与观察组各50例。对照组采用双抗疗法,观察组在对照组的治疗基础上给予丹红注射液。比较两组总有效率,治疗前后神经功能缺损评分[脑卒中美国国立卫生研究院量表(NIHSS)、改良Rankin评分(MRS)],血流变学指标[全血低切黏度(WBLV)、全血高切黏度(WBHV)、血浆黏度(PV)、红细胞比容(Hct)],凝血指标[凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白(FIB)、D-二聚体(D-D)],血脂指标[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDLC)]。结果治疗后,观察组总有效率高于对照组(P<0.05);两组NHISS、MRS评分低于治疗前,观察组NHISS、MRS评分低于对照组(P<0.05);两组WBHV、WBLV、PV低于治疗前,观察组WBHV、WBLV、PV低于对照组(P<0.05);两组治疗前后Hct差异无统计学意义(P>0.05);两组PT、APTT、TT高于治疗前,FIB、D-D低于治疗前;观察组PT、APTT、TT高于对照组,FIB、D-D低于对照组(P<0.05);两组TC、TG低于治疗前,HDL-C高于治疗前,观察组TC、TG低于对照组,HDL-C高于对照组(P<0.05)。结论丹红注射液合双抗疗法改善MACI患者神经功能,调节血液流变学、凝血、血脂水平。Objective To observe the efficacy of Danhong injection combined with bispecific antibody therapy in treatment of malignant tumors and acute cerebral infarction(MACI).Methods A total of 100 MACI patients were randomly divided into control group an observation group,with 50 cases in each group.Control group was treated with bispecific antibodies,and observation group was given Danhong Injection on the basis of control group.The total effective rate,neurological deficit scores[stroke,National Institutes of Health Scale(NIHSS),modified Rankin score(MRS)],blood rheological indexes[whole blood low cut viscosity(WBLV),whole blood high cut viscosity(WBHV),plasma viscosity(PV),hematocrit(Hct)],coagulation indicators[prothrombin time(PT),partial thromboplastin time(APTT),thrombin time(TT),fibrin(FIB),D-dimer(DD)],lipid markers[total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C)]in the two groups were compared.Results After treatment,the total effective rate of observation group was higher than that of control group(P<0.05);the scores of NHISS and MRS in both groups were lower than those before treatment,and were lower in observation group than control group(P<0.05);the scores of WBHV,WBLV,and PV in both groups were lower than those before treatment,and were lower in observation group than control group(P<0.05);there was no significant difference in Hct between the two groups before and after treatment(P>0.05);the PT,APTT,and TT levels in both groups were higher than those before treatment,while the FIB and D-D were lower,and the above indexes were superior in observation group to those in control group(P<0.05);the TC and TG of both groups were lower than those before treatment,while the HDL-C was higher,and the above indexes were superior in observation group to those in control group(P<0.05).Conclusion Danhong Injection combined with bispecific antibody therapy can improve the neurological function and regulate the hemorheology,coagulation and blood lipid levels in patients with MACI.

关 键 词：恶性肿瘤 急性脑梗死 丹红注射液 双抗疗法 

分 类 号：R273[医药卫生—中西医结合]