真武汤(参芪)加减治疗脾肾阳虚证慢性肾功能衰竭临床疗效及对血清ProGRP、微炎症的影响  

The clinical efficacy of modified Zhenwu Decoction(Shenqi)in treatment of chronic renal failure with spleen and kidney yang deficiency syndrome and its effect on serum ProGRP and microinflammation

作　　者：张亚琦 杨艳 ZHANG Ya-qi;YANG Yan(Wujin Hospital of TCM Affiliated to Nanjing University of Chinese Medicine,Changzhou 213161)

机构地区：[1]南京中医药大学附属医院武进中医医院,江苏常州213161

出　　处：《湖北中医药大学学报》2024年第5期29-32,共4页Journal of Hubei University of Chinese Medicine

基　　金：江苏省常州市科技项目(项目编号:WS202108)。

摘　　要：目的观察应用真武汤(参芪)加减治疗脾肾阳虚证慢性肾功能衰竭临床疗效及对血清胃泌素释放肽前体(ProGRP)、微炎症的影响。方法将我院80例脾肾阳虚证慢性肾功能衰竭患者随机分为对照组与观察组各40例。对照组给予调整饮食、利尿剂、糖皮质激素、血管紧张素转化酶抑制剂等常规西医治疗,观察组在对照组的治疗基础上给予真武汤(参芪)加减治疗,比较两组临床疗效、治疗前后ProGRP和白介素-6(IL-6)、白介素-8(IL-8)和糖基化终末产物(AGEs)等炎症指标水平及用药不良反应。结果治疗后,观察组总有效率显著高于对照组(P<0.05);两组ProGRP、IL-6、IL-8和AGEs低于治疗前,观察组ProGRP、IL-6、IL-8和AGEs低于对照组(P<0.05);两组不良反应发生率比较无统计学差异(P>0.05)。结论真武汤(参芪)加减与常规西医配合治疗脾肾阳虚证慢性肾功能衰竭,可提高治疗的有效性,促进肾功能的恢复,减轻机体炎症反应,且不会增加不良反应发生风险,临床应用安全性良好。Objective To observe the clinical efficacy of modified Zhenwu Decoction(Shenqi)on chronic renal failure(CRF)with spleen and kidney yang deficiency syndrome and its effects on serum gastrin-releasing peptide precursor(ProGRP)and microinflammation.Methods Eighty CRF patients with spleen and kidney yang deficiency syndrome were randomly divided into control group and observation group,with 40 cases in each group.Control group was treated with routine Western medicine such as diet adjustment,diuretics,glucocorticoids,and angiotensin-converting enzyme inhibitors;observation group was treated with modified Zhenwu Decoction(Shenqi)on the basis of control group.The clinical efficacy,levels of serum ProGRP,interleukin-6(IL-6),IL-8 and glycation end products(AGEs)before and after treatment were compared between the two groups and adverse reactions.Results After treatment,the total effective rate in observation group was higher than that in control group(P<0.05);serum ProGRP,IL-6,IL-8 and AGEs in observation group were lower than those in control group(P<0.05);there was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion Modified Zhenwu Decoction(Shenqi)combined with conventional Western medicine can improved the clnical effectiveness in treatment of chronic renal failure of spleen and kidney yang deficiency syndrom,which can promote the recovery of renal function and reduce the inflammatory response of the body without increasing the risk of adverse reactions,and the safety of clinical application is good.

关 键 词：慢性肾功能衰竭 脾肾阳虚证 真武汤(参芪) 血清胃泌素释放肽前体 白介素-6 白介素-8 糖基化终末产物 

分 类 号：R259[医药卫生—中西医结合]