A reduced graphene oxide-coated conductive surgical silk suture targeting microresistance sensing changes for wound healing  

作　　者：DING YuQi WANG XuChen LIU JingGe SHEN HongQiang WANG Zhong XIE MaoBin CHEN Ying BARCENAS Adileidys Ruiz ZHAO ZeYu LI Gang 

机构地区：[1]National Engineering Laboratory for Modern Silk,College of Textile and Clothing Engineering,Soochow University,Suzhou 215123,China [2]The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People’s Hospital,School of Biomedical Engineering,Guangzhou Medical University,Guangzhou 511436,China [3]Department of Biomedical Engineering,Tufts University,4 Colby St,Medford MA 02155,USA [4]National Sericulture Project Research Center in Plant Proteins and Bionatural Products,Havana 11300,Cuba [5]Department of Applied Physics,The Hong Kong Polytechnic University,Hong Kong 999077,China

出　　处：《Science China(Technological Sciences)》2024年第11期3499-3512,共14页中国科学（技术科学英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant No.82374295);the support of the National Key R&D Program of China(Grant No.2021YFE0111100);the Science and Technology Partnership Program by the Ministry of Science and Technology of China(Grant No.KY202201002);Jiangsu Provincial Department of Science and Technology(Grant No.BZ2022017);China National Textile and Apparel Council(Grant No.J202002)。

摘　　要：Conventional sutures used in surgical procedures often lack the capability to effectively monitor physical and chemical activities or the microbial environment of surgical wounds due to their inadequate mechanical properties,insufficient electrical accuracy and unstability.Here,we present a straightforward layer-by-layer coating technique that utilizes 3-glycidoxypropyltrimethoxysilane(CA),graphene oxide(GO),and ascorbic acid(AA)to develop conductive silk-based surgical sutures(CA-rGSFS).The CA-rGSFS feature a continuous reduced graphene oxide(rGO)film on their surface,forming robust hydrogen bonds with silk fibroin.The reduction process of rGO is confirmed through Raman analysis,demonstrating an enhanced D peak to G peak ratio.Notably,the CA-rGSFS exhibit exceptional mechanical properties and efficient electron transmission,with a knot-pull tensile strength of 2089.72±1.20 cN and an electrical conductivity of 130.30±11.34 S/m,respectively,meeting the requirements specified by the United States Pharmacopeia(USP)for 2-0 sutures.These novel CA-rGSFS demonstrate the ability to accurately track resistance changes in various fluid environments with rapid response,including saline,intestinal,and gastric fluids.The suture also retains remarkable stretchablility and stability even after enduring 3000 tensile cycles,highlighting their potential for precise surgical site monitoring during the wound healing process.

关 键 词：layer-by-layer coating reduced graphene oxide silk suture electrical conductivity microresistance sensing wound monitoring 

分 类 号：TS106.42[轻工技术与工程—纺织工程] R318.08[轻工技术与工程—纺织科学与工程]