小儿咳喘灵口服液(浓缩型)治疗儿童肺炎支原体肺炎的临床疗效观察  

Clinical efficacy observation of Xiaoer Kechuanling oral solution(concentrated)in the treatment of Mycoplasma pneumoniae pneumonia in children

作　　者：瞿圣岳 穆婧雯 杨建树 赵航宇 张秀英[2] 王雪峰[2] QU Shengyue;MU Jingwen;YANG Jianshu;ZHAO Hangyu;ZHANG Xiuying;WANG Xuefeng(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学第一临床学院,沈阳110847 [2]辽宁中医药大学附属医院儿科,沈阳110032

出　　处：《中国中西医结合儿科学》2024年第5期431-435,共5页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：基于重点研究室研究领域的中医药多学科研究能力提升项目(2022-304);国家中医药传承创新中心重点病种项目(2023-247)。

摘　　要：目的探讨小儿肺炎支原体肺炎应用小儿咳喘灵口服液(浓缩型)的临床疗效及炎性因子水平的变化情况。方法选取辽宁中医药大学附属医院儿科就诊的肺炎支原体肺炎患儿,计划纳入110例,随机分为观察组和对照组各55例。对照组用西医基础治疗,观察组在对照组治疗基础上联合小儿咳喘灵口服液(浓缩型)治疗。治疗7 d后比较两组患儿的临床疗效、症状持续时间、肺部啰音持续时间,炎性因子水平、不良反应发生情况。结果观察组总有效率为94.55%(52/55),高于对照组81.82%(45/55),差异有统计学意义(P<0.05)。观察组发热、咳嗽、咯痰、肺部啰音持续时间较对照组均明显缩短,差异有统计学意义(P<0.05)。两组治疗方案对肺炎支原体肺炎患儿TNF-α水平改善的差异无统计学意义(P>0.05)。两组治疗方案对肺炎支原体肺炎患儿IL-6水平改善的差异有统计学意义(P<0.05)。治疗期间两组不良反应发生率比较差异无统计学意义(P>0.05)。结论在西医治疗基础上,应用小儿咳喘灵口服液(浓缩型)治疗儿童肺炎支原体肺炎可有效提高临床疗效,缩短发热、咳嗽、咯痰、肺部啰音持续时间,抑制炎症反应,且安全性好。Objective To explore the clinical efficacy of Xiaoer Kechuanling oral solution(concentrated)in the treatment of children with Mycoplasma pneumoniae pneumonia and the changes in inflammatory factor levels.Methods Totally 110 children with Mycoplasma pneumoniae pneumonia who received treatment in the Pediatric Department of Liaoning University of Traditional Chinese Medicine Affiliated Hospital were selected as the research subjects.Using a random number table method,they were divided into an observation group and a control group,with 55 cases in each group.All patients received basic western medicine treatment,and the observation group received combined treatment with Xiaoer Kechuanling oral solution(concentrated)additionally.Compare the clinical efficacy,symptom improvement time,time of pulmonary rales disappearing,levels of inflammatory factors,and incidence of adverse reactions during treatment between the two groups of children.Results The total effective rate of the observation group(94.55%,52/55)was higher than that of the control group(81.82%,45/55)(P<0.05).The duration of fever,cough,expectoration,and pulmonary rales in the observation group was significantly shorter than that in the control group(P<0.05).There was no statistical difference in the improvement of the levels of tumor necrosis factor alpha(TNF-α)in these children between the two treatment regimens(P>0.05),while there was statistical difference in the improvement of IL-6 levels between the two treatment regimens(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups during the treatment period(P>0.05).Conclusion On the basis of western medicine treatment,the application of Xiaoer Kechuanling oral solution(concentrated)can effectively improve the clinical efficacy in the treatment of Mycoplasma pneumoniae pneumonia in children,shorten the duration of fever,cough,expectoration and lung rales and inhibit inflammatory reactions,and it is quite safe.

关 键 词：肺炎支原体肺炎 小儿咳喘灵口服液(浓缩型) 临床疗效 儿童 

分 类 号：R725.6[医药卫生—儿科]