海马在慢性疼痛发生发展过程中的退行性病变  

Neurodegeneration in the Hippocampus During the Progression of Chronic Pain

作　　者：胡睿涵 张衙楠 于心同[1] 冯晨晨 魏绪强 周嘉 王珂 HU Ruihan;ZHANG Ya’nan;YU Xintong;FENG Chenchen;WEI Xuqiang;ZHOU Jia;WANG Ke(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;National Engineering Center for Biochip at Shanghai,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,中国上海200437 [2]生物芯片上海国家工程研究中心,中国上海201203

出　　处：《生命科学研究》2024年第5期383-388,共6页Life Science Research

基　　金：国家自然科学基金资助项目(81973940);上海市针灸临床医学研究中心项目(20MC1920500);国家中医药管理局高水平中医药重点学科建设项目(ZYYZDXK-2023068)。

摘　　要：慢性疼痛(chronic pain)不仅引起痛苦体验,同时伴随焦虑、抑郁等负性情绪和认知功能障碍,是全球性的公共健康问题和医学问题之一。海马(hippocampus)作为边缘系统的一部分,在学习记忆能力中起着重要的作用。当前研究发现,海马在慢性疼痛的发生发展过程中发生一系列结构和功能上的改变,包括:1)神经元突触可塑性和灰质体积等结构的异常改变;2)白质功能连接、电生理特征以及相关神经环路等功能上的异常改变;3)皮质醇、肿瘤坏死因子、内源性大麻素系统、嘌呤能离子通道型受体、核因子E2相关因子2、组蛋白脱乙酰酶的异常表达。本文就海马参与慢性疼痛的形态结构、功能特征及分子机制的研究现况进行综述,为深入理解海马的重要功能提供参考。Chronic pain not only causes painful experience,but also is accompanied by anxiety,depression and other negative emotions and cognitive dysfunction.It is one of the global public health and medical problems.The hippocampus,as a part of the limbic system,plays an important role in learning and memory.Recent research has indicated that the hippocampus undergoes a sequence of structural and functional changes during the occurrence and development of chronic pain.The changes include 1)abnormal structures in neuronal synaptic plasticity and grey matter volume,2)abnormal alterations in white matter connectivity,electrophysiological characteristics,and neural circuits,and 3)abnormal expressions of cortisol,tumor necrosis factor,endogenous cannabinoid system,purinergic ion channel receptors,nuclear factor erythroid 2-related factor 2,and histone deacetylase.Herein,a comprehensive review of the morphological structure,functional characteristics,and molecular mechanisms of the hippocampus in relation to chronic pain is presented,aiming to better understand the crucial roles of the hippocampus.

关 键 词：慢性疼痛 海马 负性情绪 认知功能障碍 

分 类 号：Q426[生物学—神经生物学] R402[生物学—生理学]