子痫前期基础研究新进展  

New progress in basic research on preeclampsia

作　　者：鲁金花 王海滨 LU Jin-hua;WANG Hai-bin(Fujian Provincial Key Laboratory of Reproductive Health Research,Department of Obstetrics and Gynecology,the First Affiliated Hospital of Xiamen University,School of Medicine,Xiamen University,Xiamen 361102,China)

机构地区：[1]生殖调控与生殖健康研究福建省高校重点实验室,厦门大学附属第一医院妇产科厦门大学医学院,福建厦门361102

出　　处：《中国实用妇科与产科杂志》2024年第10期994-1002,共9页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：国家重点研发计划(2022YFC2702500,2021YFC2700302,2022YFC2704700,2022YFC2702400);国家自然科学基金(82288102,82171660)。

摘　　要：胎盘是一个临时性器官,在妊娠过程中发挥维持胎儿的生长和发育及介导母体妊娠适应等重要作用。胎盘发育过程的异常和(或)功能障碍会导致妊娠相关疾病,如子痫前期等。子痫前期是在妊娠20周以后出现的、以高血压和蛋白尿等为临床症状的妊娠相关疾病。子痫前期的病因非常复杂,但已有研究发现其主要诱因是胎盘发育异常和(或)功能障碍,子痫前期的根源是功能异常的胎盘释放“毒因子”到母体血液循环中。文章立足于正常胎盘发育过程及其调控机制,讲述子痫前期的研究模型和技术手段、基础研究新进展和基础研究成果的应用前景。The placenta is a temporary organ that plays an important role in maintaining fetal growth and development during pregnancy,as well as mediating maternal adaptation to pregnancy.Abnormalities in placental development and/or impaired function of the placenta will lead to pregnancy-related diseases,such as preeclampsia.Preeclampsia is a pregnancy-related disease that occurs after 20 weeks of pregnancy,characterized by clinical symptoms such as hypertension and proteinuria.The etiology of preeclampsia is very complex,but previous studies have found that the main cause of preeclampsia is abnormal development and/or dysfunction of the placenta.The root cause of preeclampsia is the release of"toxic factors"into the maternal circulation by the dysfunctional placenta.Based on the normal development of the placenta and its regulatory mechanisms,this article discusses the models and techniques for research in preeclampsia,new advances in basic research and their potential application.

关 键 词：胎盘发育 子痫前期 研究模型和技术手段 基础研究新进展 

分 类 号：R714.244[医药卫生—妇产科学]