正常高值血压、高血压与微量白蛋白尿的关联研究  

Association between high normal blood pressure,hypertension and microalbuminuria

作　　者：李晴 潘宁宁 刘敏[1] 李园 张普洪 白雅敏[1] 徐建伟[1] LI Qing;PAN Ningning;LIU Min;LI Yuan;ZHANG Puhong;BAI Yamin;XU Jianwei(National Center for Chronic and Noncommunicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 100050,China;The George Institute for Global Health at Peking University Health Science Center,Beijing 100088,China)

机构地区：[1]中国疾病预防控制中心慢性非传染性疾病预防控制中心,北京100050 [2]北京大学医学部乔治健康研究所,北京100088

出　　处：《预防医学》2024年第11期961-964,共4页China Preventive Medicine Journal

基　　金：英国国立健康研究院资助中英减盐项目(16/136/77)。

摘　　要：目的探讨正常高值血压、高血压与微量白蛋白尿(MAU)的关联,为高血压致肾损伤的早期筛查与预防提供依据。方法采用多阶段整群随机抽样方法,于2021年9—10月抽取河北、湖南、四川、黑龙江、青海和江西6省18~75岁常住居民为调查对象。通过问卷调查收集基本情况、生活行为等;测量身高、体重及血压等指标;测量24 h尿液中尿微量白蛋白和尿肌酐含量。采用多因素logistic回归模型分析正常高值血压、高血压与MAU的关联。结果调查1982人,<50岁996人,占50.25%;≥50岁986人,占49.75%。男性958人,占48.34%;女性1024人,占51.66%。正常血压653人,占32.95%;正常高值血压748人,占37.74%;高血压581人,占29.31%。检出MAU 164人,检出率为8.27%。正常血压、正常高值血压和高血压居民MAU检出率分别为2.14%、8.16%和15.32%,差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示,调整性别、年龄、受教育程度、吸烟、饮酒、经常锻炼和体质指数后,正常高值血压(OR=3.535,95%CI:1.898~6.585)和高血压居民(OR=7.232,95%CI:3.808~13.732)MAU风险较正常血压居民更高;高血压居民(OR=1.914,95%CI:1.340~2.735)MAU风险较正常高值血压居民更高。结论正常高值血压、高血压与MAU风险升高有关。Objective To investigate the association between high normal blood pressure,hypertension and microalbumin⁃uria(MAU),so as to provide the basis for early screening and prevention of renal injury caused by hypertension.Meth⁃ods A multi-stage cluster random sampling method was used to select permanent residents aged 18 to 75 years from six provinces including Hebei,Hunan,Sichuan,Heilongjiang,Qinghai and Jiangxi from September to October 2021.Ba⁃sic information and lifestyle behaviors were collected through questionnaires.Indices including height,weight and blood pressure were measured.Urinary microalbumin and creatinine were measured in 24-hour urine samples.The associations between high normal blood pressure,hypertension,and MAU were analyzed by using a multivariable logistic regression model.Results A total of 1982 residents were surveyed,with 996 residents aged<50 years(50.25%)and 986 resi⁃dents aged≥50 years(49.75%).There were 958 males(48.34%)and 1024 females(51.66%).Normal blood pressure was observed in 653 residents(32.95%),high normal blood pressure in 748(37.74%)and hypertension in 581(29.31%).MAU was detected in 164 participants,with a detection rate of 8.27%.The detection rates of MAU among residents with normal blood pressure,high normal blood pressure,and hypertension were 2.14%,8.16%and 15.32%,respectively,and the difference was statistically significant(P<0.05).Multivariable logistic regression analysis showed that after adjust⁃ing for gender,age,educational level,smoking,alcohol consumption,regular exercise and body mass index,the residents with high normal blood pressure(OR=3.535,95%CI:1.898-6.585)and hypertension(OR=7.232,95%CI:3.808-13.732)had higher risks of MAU compared to those with normal blood pressure;the residents with hypertension(OR=1.914,95%CI:1.340-2.735)had a higher risk of MAU compared to those with high normal blood pressure.Conclusion High normal blood pressure and hypertension are associated with an increased risk of MAU.

关 键 词：正常高值血压 高血压 微量白蛋白尿 关联 

分 类 号：R544.1[医药卫生—心血管疾病]