急性乙二醇中毒诊治研究现状  

Current status of research on the diagnosis and treatment of acute ethylene glycol poisoning

作　　者：杨凯[1] 肖克来提·霍加合买提 彭鹏[1] Yang Kai;Xiao Kelaiti·Hogahemat;Peng Peng(Emergency and Trauma Center,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学第一附属医院急救·创伤中心,乌鲁木齐830011

出　　处：《中华劳动卫生职业病杂志》2024年第10期788-793,共6页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：新疆维吾尔自治区研究生实践创新项目(XJ2023G164);新疆维吾尔自治区自然科学基金面上项目(2022D01C226)。

摘　　要：急性乙二醇中毒常导致急性肾损伤,诊断及治疗的延误会导致严重的多器官功能障碍甚至死亡。目前尚缺乏可用于临床快速诊断的特异性实验室检查方法,诊断及评估需依靠病史、临床症状及非特异性的实验室检查结果。常用治疗包括乙醇脱氢酶抑制剂(甲吡唑或乙醇)及血液透析,而特异性甲吡唑治疗药物在国内尚未批准。清楚地了解乙二醇中毒后的毒性作用机制、病理生理学、临床表现、实验室检查的有效性和局限性及治疗方案,有助于加快并完善乙二醇中毒后的早期诊断、治疗及改善患者的预后。本文就此进行综述,为临床医生提供参考。Acute ethylene glycol poisoning often leads to acute kidney injury,and delays in diagnosis and treatment can lead to severe multi-organ dysfunction and even death.At present,there is a lack of specific laboratory tests that can be used for rapid clinical diagnosis,and diagnosis and evaluation only rely on medical history,clinical symptoms,and non-specific laboratory test results.Key treatments include alcohol dehydrogenase inhibitors(fomcpizole or ethanol)and hemodialysis,which is not approved in China.A clear understanding of the mechanism of toxicity,pathophysiology,clinical manifestations,efficacy and limitations of laboratory tests,and treatment options after ethylene glycol poisoning can help accelerate the early diagnosis,treatment,and prognosis of patients after ethylene glycol poisoning.This article reviews this article in order to provide a reference for clinicians.

关 键 词：乙二醇 急性中毒 急性肾损伤 诊断 药物治疗 血液透析 

分 类 号：R595.6[医药卫生—内科学]