溶血磷脂酸在巨噬细胞中作用的分子机制及潜在临床价值  

The Molecular Mechanism and Potential Clinical Value of Lysophosphatidic Acid in Macrophages

作　　者：赵嘉怡 杨晓 杨晓云 ZHAO Jia-Yi;YANG Xiao;YANG Xiao-Yun(Department of Biochemistry and Molecular Biology,Shandong Second Medical University,Weifang 261053,Shandong,China;Department of Nursing,Shandong Second Medical University,Weifang 261053,Shandong,China;Weifang Key Laboratory of Collaborative Innovation of Intelligent Diagnosis and Treatment and Molecular Diseases,School of Basic Medical Sciences,Shandong Second Medical University,Weifang 261053,Shandong,China)

机构地区：[1]山东第二医科大学基础医学院生物化学与分子生物学系,山东潍坊261053 [2]山东第二医科大学护理学院护理学基础教研室,山东潍坊261053 [3]山东第二医科大学基础医学院智能诊疗与分子疾病协同创新重点实验室,山东潍坊261053

出　　处：《中国生物化学与分子生物学报》2024年第11期1522-1530,共9页Chinese Journal of Biochemistry and Molecular Biology

基　　金：山东省医药卫生科技发展计划项目(No.2018WS063);山东省教育厅基金项目(No.J14LK15);潍坊医学院大学生创新创业训练计划项目(No.X2021028)资助。

摘　　要：巨噬细胞是一类重要免疫细胞,主要来源骨髓中的髓系祖细胞,具有吞噬和抗原呈递、参与先天免疫和炎症反应的功能。溶血磷脂酸(lysophosphatidic acid,LPA)是一种活跃的磷脂信号分子,可以诱导巨噬细胞的分化和极化,可以调节巨噬细胞的迁移和浸润,还可以调节巨噬细胞参与的炎症反应。本文以LPA在巨噬细胞中的作用为切入点,综述了近年来LPA在巨噬细胞中作用的分子机制,LPA通过诱导相关调节因子和细胞因子,在巨噬细胞的分化和极化中发挥重要作用;LPA受体介导相关信号通路调节巨噬细胞的迁移和浸润;ATX/LPA信号轴及相关细胞因子参与巨噬细胞的炎症调节。此外,还综述了LPA在肿瘤相关巨噬细胞和巨噬细胞炎症反应疾病中的调控作用及潜在临床价值。目前,LPA在巨噬细胞中作用的分子机制尚未完全阐明,深入研究LPA在巨噬细胞中的受体表达、生物学作用及调控机制,将为巨噬细胞相关疾病和癌症的治疗提供新的策略。Macrophages are an important class of immune cells that are mainly derived from myeloid progenitor cells in the bone marrow.They function in phagocytosis and antigen presentation,and participate in innate immune and inflammatory responses.Lysophosphatidic acid(LPA)is an active phospholipid signaling molecule that induces macrophage differentiation and polarization,regulates macrophage migration and infiltration,and modulates the inflammatory response in which macrophages participate.In this paper,we review the molecular mechanisms underlying the role of LPA in macrophages in recent years by taking the role of LPA in macrophages as an entry point:LPA plays an important role in macrophage differentiation and polarization by inducing related regulatory factors and cytokines;LPA receptors mediate related signaling pathways to regulate macrophage migration and infiltration;and the ATX/LPA signaling axis and related cytokines are involved in macrophage inflammatory regulation.In addition,the regulatory role and potential clinical value of LPA in tumor-associated macrophages and macrophage inflammatory response diseases are reviewed.At present,the molecular mechanism of action of LPA in macrophages has not been fully elucidated.And an in-depth study of the receptor expression,biological roles,and regulatory mechanisms of LPA in macrophages will provide new strategies for the treatment of macrophage-associated diseases and cancers.

关 键 词：溶血磷脂酸 巨噬细胞 肿瘤免疫 癌症 细胞信号 

分 类 号：Q545[生物学—生物化学]