628例狂犬病Ⅲ级暴露者应用狂犬病人免疫球蛋白合理性的影响因素分析  

Analysis of the influencing factors on the rationality of human rabies immunoglobulin usage in 628 cases of rabies gradeⅢexposed individuals

作　　者：贺海彪 孙兆艳 付向珂 王振前 HE Haibiao;SUN Zhaoyan;FU Xiangke;WANG Zhenqian(Zoucheng Center for Disease Prevention and Control,Zoucheng,Shandong 273500,China)

机构地区：[1]邹城市疾病预防控制中心,山东邹城273500

出　　处：《中国公共卫生管理》2024年第5期729-731,735,共4页Chinese Journal of Public Health Management

摘　　要：目的 对2022年邹城市疾病预防控制中心综合门诊部狂犬病人免疫球蛋白使用情况进行合理性分析。方法 采用χ~2检验分析628例狂犬病Ⅲ级暴露者使用狂犬病人免疫球蛋白的人群特征,采用二元logistic回归分析Ⅲ级暴露者狂犬病人免疫球蛋白合理用药率的影响因素。结果 不同年龄(χ~2=18.55,P<0.01)、职业(χ~2=31.40,P<0.01)、暴露部位(χ2=11.41,P<0.05)人群合理用药率差异有统计学意义。二元logistic回归分析结果显示,职业为学生、公务人员,暴露部位为头面颈部是狂犬病人免疫球蛋白合理用药率的保护因素。结论 该门诊部在狂犬病人免疫球蛋白的使用上存在用量不适宜问题。职业、暴露部位是影响狂犬病Ⅲ级暴露者合理使用狂犬病人免疫球蛋白的因素,需针对这些影响因素采取措施,以优化合理用药。Objective To analyze the rationality of human rabies immunoglobulin usage among rabies patients in the comprehensive outpatient department of Zoucheng Center for Disease Control and Prevention in 2022.Methods A chi-square test was conducted on the population characteristics of 628 rabies gradeⅢexposed individuals who used human rabies immunoglobulin.Binary logistic regression was used to analyze the influencing factors of rational drug use retes of human rabies immunoglobulin in rabies gradeⅢexposed individuals.Results There were statistically significant differences in the rational drug use rates among populations of different ages(χ2=18.55,P<0.01),occupations(χ2=31.40,P<0.01),and exposure sites(χ2=11.41,P<0.05);binary logistic regression analysis showed that the occupation were students and government officials,exposure to the head,face,and neck were protective factors for the rational drug use rates of human rabies immunoglobulin in rabies patients.Conclusion There is an issue of inappropriate use of immunoglobulin in rabies patients in this outpatient department.Occupation and exposure site are factors that affect the rational use of human rabies immunoglobulin in rabies patients among rabies levelⅢexposed individuals,measures need to be taken to optimize rational drug use in response to these influencing factors.

关 键 词：狂犬病Ⅲ级暴露者 狂犬病人免疫球蛋白 合理用药 

分 类 号：R512.99[医药卫生—内科学] R977[医药卫生—临床医学]