双酰胺类化合物MC-1100的合成及杀虫、杀螨活性研究  

Synthesis,insecticidal-and acaricidal-activity of diamide compound MC-1100

作　　者：杨文焕 裴鸿艳 刘东东 王锋[1,3] 余裕奎 张静 张立新[1,2,3,4] YANG Wen-huan;PEI Hong-yan;LIU Dong-dong;WANG Feng;YU Yu-kui;ZHAN Jing;ZHANG Li-xi(Institute of Functional Molecules,Shenyang University of Chemical Technology,Liaoning Province Key Laboratory of Green Functional Molecular Design and Development,Shenyang Key Laboratory of Targeted Pesticides,Shenyang 110142,China;College of Materials Science and Engineering,Shenyang University of Technology,Shenyang 110870,China;College of Chemical Engineering,Liaoning University of Science and Technology,Anshan 114051,China;Metisa Biotechnology Co.,Ltd.,Nanning 530000,China)

机构地区：[1]沈阳化工大学功能分子研究所,辽宁省绿色功能分子设计与开发重点实验室,沈阳市靶向农药重点实验室,辽宁沈阳110142 [2]沈阳工业大学材料科学与工程学院,辽宁沈阳110870 [3]辽宁科技大学化学工程学院,辽宁鞍山114051 [4]广西思钺生物科技有限责任公司,广西南宁530000

出　　处：《化学研究与应用》2024年第11期2717-2723,共7页Chemical Research and Application

基　　金：南宁市创新创业领军人才“邕江计划”创业项目(2020002-1)资助;辽宁省“揭榜挂帅”科技攻关计划项目(2022JH1/10400018)资助;辽宁省自然科学基金计划项目(2022-KF-15-04)资助。

摘　　要：为了开发结构新颖的高效杀虫剂或杀螨剂,采用活性亚结构拼接策略,以邻氨基三氟甲苯和2-氟-3-硝基苯甲酸为起始原料,经8步反应,合成了双酰胺类化合物MC-1100。其结构经^(1)HNMR、碳谱以及HRMS确证。活性测试结果表明,化合物MC-1100的活性均明显优于对照药剂溴虫氟苯双酰胺。测试昆虫为二化螟时,化合物浓度设置为0.125mg·L^(-1)的条件下,化合物MC-1100具有86.67%的防治效果;测试昆虫为小菜蛾时,化合物浓度低至0.025mg·L^(-1)的条件下,化合物MC-1100也具有56.67%的防治效果;此外,10mg·L^(-1)下对朱砂叶螨的防治效果仍达97.40%。化合物MC-1100在杀虫剂领域具有重要的研究价值。To discover novel insecticide or acaricide with improved activity,a diamide compound MC-1100 was designed and synthesized on the principle of biologically active factor splicing using o-aminotrifluorotoluene and 2-fluoro-3-nitrobenzoic acid as starting materials by 8-step reaction.The structure was confirmed by'H NMR,carbon spectrum and HRMS.The activity test results showed that the activity of compound MC-1100 was significantly better than that of the control agent bromofluorobenzamide.When the test insect was chilosuppressalis,the compound MC-1100 had 86.67%control effect at the concentration of 0.125 mg·L^(-1)When the insect was plutellaxylostella,the compound MC-1100 also had 56.67%control effect at the concentration of 0.025 mg·L^(-1)In addition,the control effect against tetranychus cinnabarinus was still up to 97.40%at 10 mg·L^(-1).Therefore,compound MC-1100 had important research value in the field of insecticides.

关 键 词：双酰胺 溴虫氟苯双酰胺 杀虫活性 杀螨活性 

分 类 号：O625.52[理学—有机化学]