肥大细胞不同受体激活脱颗粒的作用和机制  

The mechanism and function of mast cell degranulation triggered by various activation-related receptors

作　　者：彭倩倩 肖辉[1] Peng Qianqian;Xiao Hui(Department of Respiratory and Critical Care Medicine,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)

机构地区：[1]上海交通大学医学院附属第一人民医院呼吸与危重症医学科,上海200080

出　　处：《国际呼吸杂志》2024年第10期1236-1240,共5页International Journal of Respiration

基　　金：国家自然科学基金(82172692);上海市第一人民医院2024年度院感课题(SYYGN202411)。

摘　　要：肥大细胞是参与免疫调节的重要效应细胞,通过脱颗粒在炎症、过敏性疾病和肿瘤的发生发展中发挥关键作用。因此,阻断受体与相应配体的作用过程以及下游的信号转导为开发具有重要临床应用潜力的药物提供研究方向。肥大细胞脱颗粒由细胞表面受体激活引起。本文围绕肥大细胞不同受体激活后脱颗粒的机制和颗粒成分的作用进行阐述。Mast cells are significant effector cells implicated in immune regulation,exerting a pivotal influence on the onset and progression of inflammation,allergic diseases,and tumors via degranulation.Therefore,blocking the interaction between receptors and corresponding ligands,as well as the downstream signaling transduction provides a valuable direction in designing relevant drugs.Mast cell degranulation is triggered by the activation of cell surface receptors.This review focused on the mechanisms of mast cell degranulation following the activation of various receptors,and the function of granule components.

关 键 词：肥大细胞 受体 脱颗粒 机制 

分 类 号：R392[医药卫生—免疫学]