阿芬太尼复合瑞马唑仑对无痛胃肠镜检查患者术后恢复质量的影响  

Effect of alfentanil combined with remimazolam on postoperative recovery quality in patients undergoing painless gastrointestinal endoscopy

作　　者：查宝珠 曹佳菲 秦倩雯 吕俊超 陈念平 ZHA Baozhu;CAOJiafei;QIN Qianwen;LYU Junchao;CHEN Nianping(Department of Anesthesiology,Affiliated Hospital,Shaoxing University,Shaoxing 312000,CHINA)

机构地区：[1]绍兴文理学院附属医院麻醉科,浙江312000

出　　处：《江苏医药》2024年第10期1016-1019,共4页Jiangsu Medical Journal

基　　金：中关村精准医学基金会(2022-1-023)。

摘　　要：目的观察阿芬太尼复合瑞马唑仑对无痛胃肠镜检查患者术后恢复质量的影响。方法行无痛胃肠镜检查患者200例随机分为两组,每组100例。两组患者诱导前静脉注射阿芬太尼6μg/kg。随后,R组静脉注射瑞马唑仑0.2mg/kg,P组静脉注射丙泊酚2mg/kg。记录两组无痛胃肠镜检查相关指标、术前及术后1d时15项恢复质量评分量表(QoR-15)评分,并观察不良反应发生情况。结果两组患者镇静有效率、检查时间、麻醉时间、意识消失时间、苏醒时间、药物追加次数及阿芬太尼使用总量比较差异均无统计学意义(P>0.05)。R组术后1d时QoR-15评分为145.00(142.00,149.75)分,高于术前的138.00(133.00,142.75)分(P<0.05);P组术后1d时QoR-15评分为145.00(142.00,149.75)分,高于术前的140.00(136.25,143.00)分(P<0.05);而两组术前及术后1d时QoR-15评分比较无统计学差异(P>0.05)。与P组比较,R组低血压、低氧血症、呼吸抑制和注射痛发生率降低(P<0.05)。结论阿芬太尼复合瑞马唑仑对无痛胃肠镜检查患者术后恢复质量的影响与阿芬太尼复合丙泊酚相仿,但术后不良反应发生率较低。Objective To observe the effect of alfentanil combined with remimazolam on the postoperative recovery quality in the patients undergoing painless gastrointestinal endoscopy.Methods A total of 200 patients undergoing painless gastrointestinal endoscopy were randomly divided into two groups,with 100 cases each.Both groups were intravenously injected with alfentanil 6μg/kg,after which group R was intravenously injected with remimazolam 0.2mg/kg and group P was intravenously injected with propofol 2mg/kg.The painless gastrointestinal endoscopy-related indicators,15-item quality of recovery rating scale(QoR-15)score before and one day after surgery were compared between the two groups.The occurrence of adverse reactions was recorded.Results There were no significant differences in the effective rate of sedation,examination time,anesthesia time,times of lost consciousness and awakening,additional drug use and total consumption of afentanil between the two groups(P>0.05).The QoR-15 score was higher one day after operation than that before operation in group R[145.00(142.00,149.75)points vs.138.00(133.00,142.75)points](P<0.05).The QoR-15 score was higher one day after operation than that before operation in group P[145.00(142.00,149.75)points vs.140.00(136.25,143.00)points](P<0.05).There was no significant difference in QoR-15 score between the two groups before and one day after operation(P>0.05).Compared with group P,the incidences of hypotension,hyoxemia,respiratory depression and injection pain were decreased in group R(P<0.05).Conclusion The effect of alfentanil combined with remimazolam on the postoperative recovery quality of the patients undergoing painless gastrointestinal endoscopy is similar to that of alfentanil combined with propofol,but the former has lower incidence of postoperative adverse reactions.

关 键 词：无痛胃肠镜 阿芬太尼 瑞马唑仑 术后恢复质量 

分 类 号：R614[医药卫生—麻醉学]