疏肝健脾和胃化浊汤加减治疗Hp感染相关性胃病的效果  

Effect of Modified Shugan Jianpi Hewei Huazhuo Decoction in Treating Hp Infection-Related Gastric Diseases

作　　者：邓勇 敖绩逃 张玉丽 DENG Yong;AO Jitao;ZHANG Yuli(TCM Department,Wanzai County People’s Hospital,Yichun 336100,China)

机构地区：[1]万载县人民医院中医科,江西宜春336100

出　　处：《基层中医药》2024年第10期25-30,共6页Basic Traditional Chinese Medicine

摘　　要：目的 研究和分析疏肝健脾和胃化浊汤加减治疗Hp(幽门螺杆菌)感染相关性胃病的效果及对中医证候、Hp转阴率的影响。方法 选择50例患者作为研究对象,均于2021年1月—2022年12月在万载县人民医院接受治疗,根据随机数字表进行分组,单数分到观察组(25例),双数分到对照组(25例)。对照组行四联疗法治疗,在对照组的基础上观察组行疏肝健脾和胃化浊汤治疗。对两组临床疗效、Hp转阴率及治疗前后中医证候积分、炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、同型半胱氨酸(Hcy)、白介素-6(IL-6)]水平变化进行观察和对比。结果 经治疗,观察组总有效率高于对照组(P <0.05)。治疗后观察组中医证候积分降低,且降低幅度比对照组显著(P <0.01)。治疗后观察组CRP、TNF-α、Hcy、IL-6水平降低,且降低幅度比对照组显著(P <0.01)。观察组Hp转阴率高于对照组(P <0.05)。结论 在四联疗法治疗的基础上对Hp感染相关性胃病行疏肝健脾和胃化浊汤加减治疗,具有更高的临床疗效,可显著改善中医证候,抑制炎性反应,提高Hp清除效果。Objective This paper aims to analyze the effect of modified Shugan Jianpi Hewei Huazhuo Decoction in treating Helicobacter pylori(Hp) infection-related gastric diseases,as well as its impact on traditional Chinese medicine(TCM) syndrome and Hp negative conversion rate.Methods Fifty patients were selected as the study subjects,all of whom received treatment at the Wanzai County People's Hospital from January 2021 to December 2022.They were divided into the observation group(n = 25 cases) and control group(n = 25 cases) based on the random number table method.The control group was treated with quadruple therapy,while the observation group was treated with Shugan Jianpi Hewei Huazhuo Decoction on the basis of the control group.The paper compared the clinical efficacy,Hp negative conversion rate,TCM syndrome scores before and after treatment,and inflammatory factors [C-reactive protein(CRP),tumor necrosis factor-alpha(TNF),homocysteine(Hcy),and interleukin-6(IL-6)] between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group(P < 0.05).The observation group showed a significant decrease in TCM syndrome scores,and the reduction was more significant than in the control group(P < 0.01).After treatment,CRP,TNF,Hcy,and IL-6 in the observation group decreased,and the reduction was more significant than in the control group(P < 0.01).The Hp negative conversion rate in the observation group was higher than that in the control group(P < 0.05).Conclusion On the basis of the quadruple therapy,the treatment of Hp infectionrelated gastric diseases with modified Shugan Jianpi Hewei Huazhuo Decoction has higher clinical efficacy,and it can significantly improve TCM syndromes,inhibit inflammatory reactions,and improve Hp clearance effect.

关 键 词：疏肝健脾和胃化浊汤 Hp感染相关性胃病 中医证候 Hp阴转率 

分 类 号：R25[医药卫生—中医内科学]