mRNA肺部递送系统研究进展  

Research progress on mRNA pulmonary delivery systems

作　　者：陈泽虹 张欣羽 邢昊楠 陆梅 孟繁 李静如 高秀丽 郑爱萍 CHEN Ze-hong;ZHANG Xin-yu;XING Hao-nan;LU Mei;MENG Fan;LI Jing-ru;GAO Xiu-li;ZHENG Ai-ping(State Key Laboratory of Functions and Applications of Medicinal Plants&School of Pharmaceutical Sciences,Guizhou Medical University,Guiyang 561l13,China;State Key Laboratory of National Security Specially Needed Medicines,Academy of Military Medical Sciences,Beijing 100850,China;Advanced Research Institute of Multidisciplinary Science,Beijing Institute of Technology,Beijing 100081,China;Microbiology and Biochemical Pharmaceutical Engineering Research Center of Guizhou Provincial Department of Education,Guizhou Medical University,Guiyang 561l13,China;Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]贵州医科大学药学院&省部共建药用植物功效与利用国家重点实验室,贵州贵阳561113 [2]军事医学研究院国家安全特需药品全国重点实验室,北京100850 [3]贵州省高校微生物生化药学工程中心,北京100081 [4]新疆医科大学,贵州贵阳561113 [5]北京理工大学前沿交叉科学研究院,新疆乌鲁木齐830054

出　　处：《药学学报》2024年第11期3074-3084,共11页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(32371440,32101157,82104105);中国博士后基金(2021M693966);国家重点研发计划(2023YFC2605000)。

摘　　要：肺部疾病是全球性的重大公共卫生问题,持续威胁着人类的生命健康并造成巨大的经济负担。基于信使RNA(messenger RNA,mRNA)的吸入制剂高效靶向肺部细胞,可克服传统疗法不良反应大、肺部生物利用度低、目标蛋白难以体外合成等问题,为治疗肺部疾病提供了新思路。然而,肺部生理结构复杂且mRNA难以进入细胞,促使人们尝试利用合适的纳米递送系统以提高递送效率。本文介绍了肺部递送需克服的屏障,讨论了mRNA肺部递送系统最新研究进展,包括脂质纳米粒、聚合物纳米粒、多肽和外泌体,总结了mRNA肺部递送系统的局限性并对mRNA吸入制剂应用前景进行展望。As a major global public health problem,pulmonary diseases threaten human life and health while causing a huge economic burden.The messenger RNA(mRNA)-based inhalation preparation,which effectively targets pulmonary cells can overcome the problems of traditional therapy,such as high side effects,low pulmonary bioavailability,and difficulty in synthesizing target proteins in vitro,thus providing new ideas for the treatment of pulmonary diseases.However,as the lung structure is complex and mRNA has trouble entering cells,researchers have been attempting to develop a suitable nano delivery system for higher delivery efficiency.This review introduces the barriers to pulmonary delivery,discusses the recent research development of the mRNA pulmonary delivery systems,including lipid nanoparticles,polymeric nanoparticles,polypeptides and exosomes,summarizes their limitations and looks forward to the application of mRNA inhalation preparations.

关 键 词：MRNA 吸入制剂 肺部递送 肺部屏障 纳米递送系统 疫苗 

分 类 号：R943[医药卫生—药剂学]