超声激励微泡空化在新型辅助治疗中的应用及进展  

Application and progress of ultrasound-stimulated microbubble cavitation in novel adjuvant therapies

作　　者：刘奕佳 汤晓轶 赵佳琦 LIU Yijia;TANG Xiaoyi;ZHAO Jiaqi(Department of Ultrasound,The Second Affiliated Hospital of Naval Medical University(Second Military Medical University),Shanghai 200003,China;Department of Ultrasound,Shanghai Fourth People’s Hospital Affiliated to Tongji University,Shanghai 200434,China)

机构地区：[1]海军军医大学(第二军医大学)第二附属医院超声诊断科,上海200003 [2]同济大学附属上海市第四人民医院超声医学科,上海200434

出　　处：《海军军医大学学报》2024年第11期1419-1424,共6页Academic Journal of Naval Medical University

基　　金：国家自然科学基金(81501492);上海市自然科学基金(20ZR1457900);上海市虹口区卫生健康委员会医学科研课题(虹卫2302-26);上海市虹口区卫生健康委员会临床重点扶持专科项目(HKLCFC202404);海军军医大学(第二军医大学)第二附属医院人才建设三年行动计划——“金字塔人才工程”军事医学人才项目(1009);同济大学附属上海市第四人民医院科研启动专项(SYKYQD06101);同济大学附属上海市第四人民医院学科助推计划临床研究重点项目(SY-XKZT-2023-2002).

摘　　要：超声激励微泡空化(USMC)是超声场中震荡微泡引发的空化现象,该效应已在提高细胞膜的通透性、增强肿瘤细胞对化疗或免疫治疗的敏感性及增加溶栓药物对血栓渗透和血管再通方面取得了突破性进展。近年来,超声医学与材料学的交叉融合催生了超声响应性多功能纳米级微泡的研究,提升了USMC治疗效果。本文综述了USMC在改善缺血疾病的组织灌注、肿瘤化疗和免疫治疗、超声溶栓等方面的应用及研究进展。Ultrasound-stimulated microbubble cavitation(USMC)is a cavitation phenomenon triggered by oscillating microbubbles in ultrasound field,and this effect has led to breakthroughs in improving the permeability of cell membranes,enhancing the sensitivity of tumor cells to chemotherapy or immunotherapy,and increasing the penetration of thrombolytic drugs into blood clots and vascular recanalization.In recent years,the cross-fertilization of ultrasound medicine and materials science have given rise to the study of ultrasound-responsive multifunctional nanobubble to enhance USMC treatment.This article reviews the application and research progress of USMC in improving tissue perfusion in ischemic diseases,tumor chemotherapy and immunotherapy,ultrasonic thrombolysis,and other treatments.

关 键 词：超声疗法 超声造影剂 纳米技术 空化疗法 肌骨超声 

分 类 号：R454.3[医药卫生—治疗学]