仙灵骨葆胶囊治疗早期股骨头缺血性坏死的疗效观察  

Therapeutic Effect of Xianling Gubao Capsule(仙灵骨葆胶囊)on Early Ischemic Necrosis of Femoral Head

作　　者：刘英杰 韩昆[2] 苏敬彬 彭光远 何晓辰 王金榜[6] LIU Yingjie;HAN Kun;SU Jingbin;PENG Guangyuan;HE Xiaochen;WANG Jinbang(Department of Traditional Chinese Medicine,The First Affiliated Hospital of Hebei University of Traditional Chinese Medicine,Shijiazhuang 050033,Hebei,China;Department of Bone Injury,Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,Hebei,China;Department of Orthopedic Injuries,Yiling hospital,Shijiazhuang 050011,Hebei,China;Department of Bone,Dongtai Hospital of Traditional Chinese Medicine,Dongtai 224200,Jiangsu,China;Department of Rehabilitation Medicine,Hebei Provincial People′s Hospital,Shijiazhuang 050000,Hebei,China;Traditional Chinese Medicine Characteristic Research Laboratory,Hebei Provincial Traditional Chinese Medicine Hospital,Shijiazhuang 050000,Hebei,China)

机构地区：[1]河北中医药大学,河北中医药大学第一附属医院,中医药特色研究室,河北石家庄050033 [2]河北省中医院骨伤一科,河北石家庄050000 [3]河北以岭医院骨伤二科,河北石家庄050011 [4]东台市中医院骨一科,江苏东台224200 [5]河北省人民医院康复医学科,河北石家庄050000 [6]河北省中医院,中医药特色研究室,河北石家庄050000

出　　处：《辽宁中医杂志》2024年第11期77-80,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2018044)。

摘　　要：目的探讨仙灵骨葆胶囊联合冲击波对早期股骨头缺血性坏死患者血清细胞因子水平和骨密度的影响。方法采用随机数字表法将2020年6月—2022年6月河北中医学院附属医院收治的100例早期股骨头缺血性坏死患者分为A组和B组,各50例。两组均给予冲击波治疗,B组在此基础上给予仙灵骨葆胶囊。两组持续治疗1个月。比较两组治疗1个月后的临床疗效,治疗前、治疗1个月后的髋关节活动度、髋关节功能、疼痛程度、骨密度、影像学指标及血清细胞因子水平。结果治疗1个月后,B组总有效率高于A组[96.00%(48/50)vs 70.00(35/50),P<0.05]。与治疗前比较,治疗1个月后,两组髋关节屈曲、外展、外旋活动度、Harris评分、髋关节股骨粗隆、股骨颈、Ward′s三角骨密度、骨坏死区灰度、股骨头灰度及血清转化生长因子-β(transforming growth factor-β,TGF-β)、骨形态发生蛋白(bone morphogenetic protein,BMP)、骨碱性磷酸酶(bone alkaline phosphatase,BAP)水平均升高,且B组高于A组;视觉模拟评分(visual analogue scale,VAS)、骨坏死区体积及血清N-端骨钙素(N-terminal osteocalcin,N-MID)、总Ⅰ型前胶原氨基端前肽(total type I procollagen amino terminal peptide,P1NP)水平均降低,且B组低于A组(P<0.05)。结论仙灵骨葆胶囊联合冲击波治疗可有效调节早期股骨头缺血性坏死患者相关血清因子水平,改善患者骨密度,进一步可提高患者髋关节功能及活动度,改善影像学指标,并有效缓解患者疼痛度,进而可提高临床疗效。Objective To explore the effect of Xianling Gubao Capsule(仙灵骨葆胶囊)combined with shock wave on levels of serum cytokine and bone density in patients with early ischemic necrosis of the femoral head.Methods A hundred patients with early ischemic necrosis of the femoral head admitted to the Affiliated Hospital of Hebei University of Traditional Chinese Medicine from June 2020 to June 2022 were divided into group A and group B by random number table method,50 cases in each group.Both groups were treated with shock wave therapy,while group B was treated with Xianling Gubao Capsule on this basis.Both groups continued treatment for 1 month.The clinical efficacy after 1 month of treatment,including hip joint range of motion,hip joint function,pain level,bone density,imaging indicators and levels of serum cytokine before and after 1 month of treatment of two groups were compared.Results After 1 month of treatment,the rate of total effective in group B was higher than that in group A[96.00%(48/50)vs 70.00%(35/50),P<0.05].Compared with those before treatment,after 1 month of treatment,the hip flexion,abduction,external rotation activity,the score of Harris,bone densities of hip femoral trochanter,neck of femur,Ward′s triangle,bone necrosis area gray,femoral head gray and levels of serum transforming growth factor-β(TGF-β),bone morphogenetic protein(BMP)and bone alkaline phosphatase(BAP)of the two groups increased,and the scores and levels of group B were higher than those of group A.The score of visual analogue scale(VAS),osteonecrosis area volume and levels of serum N-terminal osteocalcin(N-MID)and total type I procollagen amino terminal peptide(P1NP)all decreased,and the levels of group B were lower than those of group A(P<0.05).Conclusion Xianling Gubao Capsule combined shock wave therapy could effectively regulate the levels of serum factors related to early avascular necrosis of the femoral head in patients,increase the bone density,further enhance the hip joint function and mobility,improve the imaging

关 键 词：早期股骨头缺血性坏死 冲击波 仙灵骨葆胶囊 骨密度 

分 类 号：R274[医药卫生—中医骨伤科学]