小青龙汤合九味羌活汤治疗寒湿犯肺型慢性阻塞性肺疾病疗效  

Effect of Xiaoqinglong Decoction(小青龙汤)Combined with Jiuwei Qianghuo Decoction(九味羌活汤)on Chronic Obstructive Pulmonary Disease Caused by Cold-Dampness

作　　者：王兵 陈虎林 宋功如 WANG Bing;CHEN Hulin;SONG Gongru(Department of Traditional Chinese Medicine,The Eighth People′s Hospital of Hefei,Hefei 238000,Anhui,China)

机构地区：[1]合肥市第八人民医院中医科,安徽合肥238000

出　　处：《辽宁中医杂志》2024年第11期127-130,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的探讨小青龙汤合九味羌活汤治疗寒湿犯肺型慢性阻塞性肺疾病疗效。方法选取该院2020年1月—2022年1月收治的80例寒湿犯肺型慢性阻塞性肺疾病患者作为研究对象,按照随机数字表法分为观察组40例(给予小青龙汤合九味羌活汤治疗)和对照组40例(给予九味羌活汤治疗)。观察治疗后的临床疗效、症状积分、肺功能情况、炎症反应、不良反应。结果治疗后,观察组患者的总有效率为95.00%(38/40),高于对照组患者的80.00%(32/40)(P<0.05)。治疗前,两组患者的咳嗽、喘息、发热、鼻塞、肢体酸痛等症状积分比较,数据差异无统计学意义(P>0.05);治疗后,观察组咳嗽、喘息、发热、鼻塞、肢体酸痛等症状积分均低于对照组,数据差异有统计学意义(P<0.05)。治疗前,两组患者的用力肺活量(forced vital capacity,FVC)、每分钟最大通气量(maximal voluntary ventilation,MVV)、第1秒用力呼气量(forced expiratoryvolume in one second,FEV_(l))、第1秒呼气率(FEV_(l)/FVC)、峰值呼气流速(peak expiratory flow,PEF)比较,数据差异无明显统计学意义(P>0.05);治疗后,观察组患者的FVC、FEV_(l)、FEVl/FVC、MVV、PEF水平均高于对照组患者,数据差异有统计学意义(P<0.05)。治疗前,两组患者白细胞介素-6(interleukin,IL-6)、肿瘤坏死因子-α(tumor necrosis factorα,TNF-α)值比较,数据差异无统计学意义(P>0.05);治疗后,观察组患者的IL-6、TNF-α值分别为(53.41±2.22)pg/mL、(78.12±2.24)pg/mL,均低于对照组患者的(62.67±3.19)pg/mL、(82.25±3.19)pg/mL,数据差异有统计学意义(P<0.05)。观察组患者不良反应发生率与对照组患者比较(P>0.05)。结论小青龙汤合九味羌活汤治疗寒湿犯肺型慢性阻塞性肺疾病能够提高患者的临床疗效,改善中医证候积分以及肺功能情况,降低体内炎症介质水平,安全性较高,值得临床推广。Objective To explore the effect of Xiaoqinglong Decoction(小青龙汤)combined with Jiuwei Qianghuo Decoction(九味羌活汤)on chronic obstructive pulmonary disease caused by cold-dampness.Methods Eighty patients with chronic obstructive pulmonary disease(COPD)of cold-dampness attackinglungtype who were admitted to the hospital from January 2020 to January 2022 were selected as the research objects,and were randomly divided into the observation group(40 cases,treated with Xiaoqinglong Decoction and Jiuwei Qianghuo Decoction)and the control group(40 cases,treated with Jiuwei Qianghuo Decoction).The clinical effect,symptom scores,pulmonary function,inflammatory reaction and adverse reaction were observed after treatment.Results After treatment,the total effective ratein the observation group was 95.00%,which was higher than 80.00%in the control group(P<0.05).Before treatment,the scores of cough,wheezing,fever,nasal congestion,limb pain and other symptoms of the two groupshad no significant difference in data(P>0.05).After treatment,the scores of cough,wheezing,fever,nasal congestion,limb pain and other symptoms in the observation group were lower than those in the control group,and the data difference was statistically significant(P<0.05).Before treatment,there was no significant difference in forced vital capacity(FVC),maximum ventilation(MVV),forced expiratory volume in one second(FEV_(l)),FEVl/FVCor peak expiratory flow(PEF)between the two groups(P>0.05).After treatment,the levels of FVC,FEV_(l),FEV_(l)/FVC,MVV and PEF in the observation group were higher than those in the control group,and the data difference was statistically significant(P<0.05).Before treatment,the levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)had no significant difference between the two groups(P>0.05).After treatment,the levels of IL-6 and TNF-αof patients in the observation groupwere(53.41±2.22)pg/mL and(78.12±2.24)pg/mL,respectively,which were lower than those in the control group[(62.67±3.19)pg/mL and(82.25±3.1

关 键 词：小青龙汤 九味羌活汤 寒湿犯肺型慢性阻塞性肺疾病 肺功能 

分 类 号：R256.1[医药卫生—中医内科学]