中医药治疗心肌纤维化的研究进展  

Research Progress in the Treatment of Myocardial Fibers with Traditional Chinese Medicine

作　　者：朱昱熹 张梦钰 杨林 熊小英 陈果 裴兆辉 ZHU Yuxi;ZHANG Mengyu;YANG Lin;XIONG Xiaoying;CHEN Guo;PEI Zhaohui(Jangxi University of Chinese Medicine,Nanchang 330000,Jiangxi,China;Nanchang People’s Hospital,Nanchang 330000,Jiangxi,China;Department of Acupuncture,Baoan Authentic Traditional Chinese Medicine Therapy Hospital,Shenzhen 518000,Guangdong,China)

机构地区：[1]江西中医药大学,江西南昌330000 [2]南昌市人民医院,江西南昌330000 [3]深圳市宝安纯中医治疗医院,广东深圳518000

出　　处：《实用中医内科杂志》2024年第11期42-46,共5页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金项目(8206080443)。

摘　　要：心肌纤维化是一种存在于心血管疾病发展过程中的病理状态。心肌纤维化主要由心肌细胞外基质蛋白和肌成纤维细胞的过度囤积所导致。目前西医对于该疾病的治疗缺乏疗效确切的治疗方式,一般采用药物、手术等治疗,但是费用高和不良反应大。中医历史源远流长,依据心肌纤维化的临床症状,认为可纳入“心悸”“胸痹”“喘证”等疾病,常归因于外邪侵扰、饮食不洁、情志不遂、久病劳累等病因,在病机中常辨证于本虚标实等。中医药在心肌纤维化的治疗中具有独特见解,可通过中药及中药复方治疗,改善疾病临床症状,且中药治疗费用较低、不良反应较小,有利于患者疾病恢复,缓解患者经济压力。文章搜集了近年文献资料,针对不同中药、经方及复方对于认识及治疗心肌纤维化的研究等方面进行梳理与归纳,为中西医药治疗心肌纤维化的研究提供新思路与方向。Cardiovascular diseases can be caused by the presence of myocardial fibrosis.Excessive buildup of extracellular matrix proteins and myofibroblasts is the primary cause of myocardial fibrosis.Currently,Western medicine does not provide a definitive and effective solution to the disease,often involving drugs,surgery,and other treatments;however,the associated costs and side effects are considerable.The clinical symptoms of myocardial fibrosis suggest that Tcm has a lengthy background,encompassing conditions such as"palpitations,""chest paralysis,""wheezing syndrome,"and various other diseases,frequently linked to external intrusions,unhealthy eating habits,mood disorders,chronic fatigue,and more,often exhibiting a dialectical nature in the development of this deficiency.Traditional Chinese medicine provides a distinctive perspective on the management of myocardial fibrosis.The combination of tcm and tcm therapy can alleviate the clinical symptoms of the disease,while the tcm treatment is more cost-effective and has fewer side effects,thus allowing patients to recuperate from the illness and reduce their financial burden.This paper collates the literature from recent years,and synthesizes the studies of various traditional Chinese medicine,prescriptions,and compounds on the comprehension and management of myocardial fibrosis,with the aim of offering novel concepts and pathways for the exploration of Chinese and western medicine in the treatment of myocardial fibrosis.

关 键 词：中医药 心肌纤维化 单药 经方 复方 研究进展 

分 类 号：R256.1[医药卫生—中医内科学]