中医药治疗糖尿病肾病的作用机制研究进展  

Research Progress of Chinese Medicine Intervention in Diabetic Nephropathy-related Pathways

作　　者：靳丁霞 王志刚 JIN Dingxia;WANG Zhigang(Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China;Gansu Tianshui Hospital of Traditional Chinese Medicine,Tianshui 741099,Gansu,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]天水市中医院,甘肃天水741099

出　　处：《实用中医内科杂志》2024年第11期130-133,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：甘肃省中医药科研项目(GZKP-2021-46)。

摘　　要：糖尿病肾病是糖尿病最常见的并发症之一,也是导致终末期肾病的主要原因。其发病机制涉及多个信号通路和作用靶点,包括炎症、细胞焦亡、氧化应激、纤维化等,且它们之间相互影响。西医治疗主要依赖扩张血管为主但是作用有限。中药作为一种多组分、多靶点的药物,能够针对糖尿病肾病的多个信号通路发挥协同作用,具有较好的治疗潜力。文章综述了近年来关于糖尿病肾病的信号通路和中医药干预的分子机制,旨在为临床及实验研究提供新思路。Diabetic kidney disease is one of the most common complications of diabetes mellitus and a major cause of end-stage renal disease.Its pathogenesis involves multiple signaling pathways and targets of action,including inflammation,cellular scorching,oxidative stress,and fibrosis,and they interact with each other.Western medicine treatment mainly relies on vasodilatation,which has limited effects.Chinese medicine,as a multi-component and multi-target drug,can exert synergistic effects on multiple signaling pathways in diabetic kidney disease and has a better therapeutic potential.In this paper,we review the signaling pathways and molecular mechanisms of TCM interventions in diabetic kidney disease in recent years,aiming to provide new ideas for clinical and experimental research.

关 键 词：中医药 糖尿病肾病 信号通路 炎症 氧化应激 

分 类 号：R256.5[医药卫生—中医内科学]