2型糖尿病患者胰岛素抵抗与尿酸/高密度脂蛋白胆固醇比值的相关性研究  

Association study between insulin resistance and uric acid/high-density lipoprotein cholesterol ratio in patients with type 2 diabetes mellitus

作　　者：黄献雨 郭立民[2] 李祥[1] 戴书连 李圣平 陈娣 刘燕[1] HUANG Xian-yu;GUO Li-min;LI Xiang(Department of Clinical Laboratory,Chuzhou Hospital of Integrated Traditional Chinese and Western Medicine,Chuzhou Anhui 239000,China;Department of Endocrinology,Chuzhou Hospital of Integrated Traditional Chinese and Western Medicine,Chuzhou Anhui 239000,China)

机构地区：[1]滁州市中西医结合医院检验科,安徽滁州239000 [2]滁州市中西医结合医院内分泌科,安徽滁州239000

出　　处：《临床和实验医学杂志》2024年第20期2168-2172,共5页Journal of Clinical and Experimental Medicine

基　　金：安徽省中医药传承创新科研项目(编号:2022CCYB10)。

摘　　要：目的探讨2型糖尿病(T2DM)患者胰岛素抵抗与尿酸/高密度脂蛋白胆固醇比值(UHR)的相关性。方法本研究为一项前瞻性研究,收集2021年1月1日至2024年3月1日于滁州市中西医结合医院内分泌科治疗的T2DM患者98例,根据稳态模型胰岛素抵抗指数(HOMA-IR)将所有患者分为胰岛素抵抗组(n=38)和非胰岛素抵抗组(n=60)。比较两组患者的临床参数(年龄、性别、体重指数、病程、吸烟史、饮酒史、高血压史)和生化指标[空腹血糖、糖化血红蛋白、空腹胰岛素、胰岛素抵抗、总胆固醇、甘油三脂、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿酸、肌酐]水平。采用Pearson相关性分析胰岛素抵抗与生化指标之间的相关性,多因素Logistic回归分析胰岛素抵抗的危险因素。结果胰岛素抵抗组患者的年龄、体重指数、合并高血压比率分别为(55.92±13.28)岁、(24.17±5.36)kg/m^(2)、47.37%,均明显高于非胰岛素抵抗组[(62.51±12.73)岁、(27.92±4.81)kg/m^(2)、26.67%],差异均有统计学意义(P<0.05)。胰岛素抵抗组患者的空腹血糖、糖化血红蛋白、空腹胰岛素、胰岛素抵抗、甘油三脂、LDL-C、尿酸、肌酐及UHR水平分别为(11.01±4.10)mmol/L、(9.83±2.41)%、(10.74±4.99)μIU/mL、5.11±2.83、(2.31±1.34)mmol/L、(2.98±1.45)mmol/L、(439.87±90.56)μmol/L、(103.06±54.25)μmol/L、(22.92±8.72)%,均明显高于非胰岛素抵抗组[(6.99±1.73)mmol/L、(7.35±2.26)%、(4.60±1.59)μIU/mL、2.34±1.30、(0.97±0.25)mmol/L、(2.01±1.27)mmol/L、(357.98±89.74)μmol/L、(69.42±27.81)μmol/L、(16.53±7.32)%],血清HDL-C水平为(0.89±0.41)mmol/L,明显低于非胰岛素抵抗组[(1.21±0.35)mmol/L],差异均有统计学意义(P<0.05);两组总胆固醇比较,差异无统计学意义(P>0.05)。Pearson相关性分析显示胰岛素抵抗与体重指数、空腹血糖、糖化血红蛋白、空腹胰岛素、甘油三脂、LDL-C、肌酐及UHR呈正相关,与HDL-C呈负相Objective To investigate the correlation between insulin resistance and uric acid/high-density lipoprotein cholesterol ratio(UHR)in patients with type 2 diabetes mellitus(T2DM).Methods This study was a prospective study.A total of 98 patients with T2DM who were hospitalized in the Department of Endocrinology of Chuzhou Integrated Traditional Chinese and Western Medicine Hospital from January 1,2021 to March 1,2024 were collected.All patients were divided into insulin resistance group(n=38)and non-insulin resistance group(n=60)according to the homeostatic model assessment of insulin resistance index(HOMA-IR).The clinical data(age,gender,body mass index,course of disease,smoking,drinking,hypertension)and biochemical index[fasting blood glucose,glycosylated hemoglobin,fasting insulin,insulin resistance,total cholesterol,triglycerides,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),uric acid,creatinine]levels of patients in two groups were compared.The correlation between insulin resistance and biochemical indices was analyzed by Pearson correlation analysis.The risk factors of insulin resistance was analyzed using multifactorial Logistic regression analysis.Results The age,body mass index and hypertension rate in the insulin resistance group were(55.92±13.28)years,(24.17±5.36)kg/m^(2)and 47.37%,respectively,which were significantly higher than those in the non-insulin resistance group(62.51±12.73)years,(27.92±4.81)kg/m^(2)and 26.67%,the differences were statistically significant(P<0.05).The levels of fasting blood glucose,glycosylated hemoglobin,fasting insulin,insulin resistance,triglyceride,LDL-C,uric acid,creatinine and UHR in insulin resistance group were(11.01±4.10)mmol/L,(9.83±2.41)%,(10.74±4.99)μIU/mL,5.11±2.83,(2.31±1.34)mmol/L,(2.98±1.45)mmol/L,(439.87±90.56)μmol/L,(103.06±54.25)μmol/L,(22.92±8.72)%,respectively,which were significantly higher than those in the non-insulin resistance group[(6.99±1.73)mmol/L,(7.35±2.26)%,(4.60±1.59)μIU/mL,2.34±1.30,

关 键 词：2型糖尿病 胰岛素抵抗 尿酸/高密度脂蛋白胆固醇比值 

分 类 号：R587.1[医药卫生—内分泌]