银杏酮酯分散片在脑梗死二级预防中的应用及其对颈动脉斑块面积、血液流变学及炎症水平的影响  

Effects of ginkgo ester dispersive tablets for secondary prevention of cerebral infarction on carotid plaque area,hemorheology and inflammation level

作　　者：凌丽芬 王思潇 李维 LING Li-fen;WANG Si-xiao;LI Wei(Department of Pharmacy,922 Hospital,Joint Logistic Support Force,PLA,Hengyang Hunan 421002,China)

机构地区：[1]中国人民解放军联勤保障部队第九二二医院药剂科,湖南衡阳421002

出　　处：《临床和实验医学杂志》2024年第19期2029-2034,共6页Journal of Clinical and Experimental Medicine

基　　金：湖南省自然科学基金项目(编号:2020JJ8101)。

摘　　要：目的探究银杏酮酯分散片在脑梗死二级预防中的应用及其对颈动脉斑块面积、血液流变学及炎症水平的影响。方法前瞻性选取将2020年6月至2023年6月中国人民解放军联勤保障部队第九二二医院收治的155例脑梗死患者作为本研究对象,按照随机数字表法将患者分为对照组(n=77)和研究组(n=78)。对照组患者接受脑梗死二级预防常规干预治疗,研究组患者在对照组的基础上加用银杏酮酯分散片进行治疗。比较两组治疗后1个月的治疗效果,观察、治疗前及治疗后1个月的颈动脉斑块面积变化情况[颈动脉内中膜厚度(IMT)、颈动脉斑块积分、斑块面积]、血液流变学指标(全血低切及高切黏度、血浆黏度、红细胞压积、红细胞聚集指数)及炎症反应[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、血脂(总胆固醇、甘油三酯)情况,并记录治疗期间不良反应的发生情况。结果研究组患者的治疗有效率为92.31%,高于对照组(80.52%),差异有统计学意义(P<0.05)。治疗后1个月,两组颈动脉状况均较治疗前有所改善,且研究组IMT、颈动脉斑块积分、斑块面积分别为(1.03±0.25)mm、(3.44±0.39)分、(17.13±0.37)mm 2,均低于对照组[(1.15±0.12)mm、(3.74±0.66)分、(20.11±0.34)mm 2],差异均有统计学意义(P<0.05)。治疗前,两组组间的斑块面积、颈动脉斑块积分、IMT比较,差异均无统计学意义(P>0.05),治疗前,研究组、对照组组间全血低切及高切黏度、红细胞压积、红细胞聚集指数、血浆黏度比较,差异均无统计学意义(P>0.05),治疗后1个月,两组患者全血低切及高切黏度、血浆黏度、红细胞压积、红细胞聚集指数血液流变学各项指标均较治疗前降低,且研究组全血低切及高切黏度、血浆黏度、红细胞压积、红细胞聚集指数分别为(36.55±2.12)mPa·s、(4.08±0.76)mPa·s、(0.77±0.29)mPa·s、6.47±0.31、(33.12±6.18)%,Objective To investigate the application of Ginkgo Biloba Terpene Lactones Dispersible Tablets in secondary prevention of cerebral infarction and their impacts on carotid artery plaque area,hemorheology,and inflammation levels.To investigate the effects of ginkgo ester dispersive tablets for secondary prevention of cerebral infarction on carotid plaque area,hemorheology and inflammation level.Methods A total of 155 patients with cerebral infarction admitted to 922 Hospital,Joint Logistic Support Force,PLA from June 2020 to June 2023 were prospectively selected as the subjects of this study.The patients were divided into the control group(n=77)and the study group(n=78)according to the random number table method.The patients in the control group received routine intervention for secondary prevention of cerebral infarction,and the patients in the study group were treated with ginkgo ketone ester dispersible tablets on the basis of the control group.The therapeutic effect of the two groups was compared at one month after treatment.The changes of carotid plaque area[carotid intima-media thickness(IMT),carotid plaque score,plaque area],hemorheological indexes(whole blood low shear and high shear viscosity,plasma viscosity,hematocrit,erythrocyte aggregation index)and inflammatory response[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],blood lipids(total cholesterol,triglyceride)were observed before and one month after treatment.The occurrence of adverse reactions during treatment was recorded.Results The effective rate of treatment in the study group was 92.31%,which was higher than that in the control group(80.52%),and the difference was statistically significant(P<0.05).One month after treatment,the carotid artery status of the two groups was improved compared with that before treatment,and the IMT,carotid plaque score and plaque area of the study group were(1.03±0.25)mm,(3.44±0.39)points and(17.13±0.37)mm 2,respectively,which were lower than those of the control g

关 键 词：银杏酮酯 二级预防 脑梗死 颈动脉斑块 血液流变学 炎症因子 

分 类 号：R277.7[医药卫生—中医学]